Статьи журнала - Cardiometry
Все статьи: 606
Статья научная
Background: Global left ventricular (LV) myocardial work effi-ciency (GLVMWE); the ratio of constructive to wasted work in all LV segments, reflects the efficiency by which mechanical energy is expended during the cardiac cycle. Global LV myocardial work efficiency (GLVMWE) can be derived from LV pressure-strain loop analysis incorporating both noninvasively estimated blood pressure recordings and echocardiographic strain data.
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Статья научная
Acute myocardial infarction causes a great number of mortality and morbidity each year. Risk assessment and prognosis is one of the initial steps in approaching a patient with acute myocardial infarction. Neutrophil to lymphocyte ratio (NLR) and red cell distribution width to platelet ratio (RPR) are two indices that have been studied recently and their prognostic and risk assessment role is reported in various studies. In this study we aimed to investigate the relationship between NLR and RPR with ST segment resolution (STR) in patients with acute myocardial infarction. Materials and methods This is a cohort study with 2 months of follow up and a total of 211 patients with acute myocardial infarction were enrolled in the study. An electrocardiogram and venous blood sample was taken from all included patient and the results were recorded in a questionnaire. All patients underwent primary coronary intervention and another electrocardiogram was retrieved within 90 minute after primary angioplasty. Data was analyzed using SPSS 16. Results Our results showed that the mean age of participants was 61.15±12.68 years. Among 211 patients, 181 (85.8%) were male and 30 (14.2%) were female. The mean RPR, NLR and SRT in the studied patients was 1.01±0.21, 4.07±3.31 and 0.418±0.32 respectively. There was a significant correlation between NLR and RPR with STR along with two month complications in studied patients. Conclusion According to our results, NLR and RPR can be used for risk assessment and prognosis and short term complications of myocardial infarction in patients undergoing primary coronary intervention.
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Counselling to promote self-esteem -pilot analysis
Статья научная
Alcohol is not able to control the drinking habit due to both physical and emotional dependence on alcohol. Counseling aims to address the underlying causes of alcoholism. Alcohol is classified as a ‘brain disease’. Counseling services are therefore an important factor in recovering from addiction and promoting self-esteem. Self-esteemis a reflection of human understanding and a sense of human worth. Counseling is a method that helps to use a problem-solving process to promote self-esteem. This study aims to determine the effectiveness of counseling, promote self-esteem, and link self-esteem with demographic variability. Post-counseling study methodology after counseling, in the Study group, 8.33% of alcohol dependents had a low score, 50% alcohol dependence had a moderate level of the score and 41.67% was a high score. Among the control group, 41.67% of alcohol dependents had a low score, 58.33% received a moderate level and none of them achieved a high score. Therefore, counseling provides professional support, advice, and recommended addiction services.
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Criteria of identification of individual heart cycle phases on ECG
Статья научная
Aims Criteria of identification of individual heart cycle phases according to an ECG curve are described in this paper. Materials and For this study, a single-lead system ECG is used only. Its distinctive methods feature is that an ECG signal is recorded within the body surface area of the ascending aorta. Using the theory of biological system process continuity, the individual heart cycle phase boundaries are determined at those points of the cardiac signals where we deal with an energy process transition in the cardiovascular system from the process of the energy build-up to its attenuation, and vice versa. The transition points are identified by us by mathematical differentiation of the ECG signals, and, as a result, they correspond to extrema of the ECG derivative. Some individual heart cycle phases are found according to maxima on the derivative, others are identified according to minima on the derivative curve, respectively. Results The method of application of the ECG derivatives allows to capture individual heart cycle phases in a very precise manner. Utilization of the ECG derivatives is a prerequisite for computer-assisted processing of the data to deliver measurements of durations of every heart cycle phase. Conclusion Using the ECG derivatives for fixing every heart cycle phase makes possible to fill up the gaps in the theory of phase analysis and avoid misinterpretations of any type of the ECG phase structures.
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Cybernetic approach to health assessment
Статья научная
The exploration of orbital space served as a prerequisite for the creation of a new direction of medical science in relation to the very extreme conditions of life of spacecraft crews. Space medicine, relying on the most modern research methods and approaches, thanks to the development of new medical devices and the use of unique data analysis algorithms, has made a significant contribution to the development of telemedicine, medical cybernetics, and prenosological principles for assessing the state of human health. The review reflects the main stages in the development of medical cybernetics and prenosological diagnostics based on the assessment of the regulatory components of the cardiovascular system. Discussed the aspects of the application of the method of mathematical analysis of the heart rhythm in relation to the assessment and forecast of the working capacity of cosmonauts, at the simulating model of microgravity and confinement. Shown the useful methodically apply for the healthcare of manufacture teams at the plants, passenger bus driver’s employments. As the part of appliance of the new advance tools of children and adolescents public health during the educating process at schools. The created system for analyzing the current functional state of human health and mathematical models that make it possible to predict its negative changes make it possible to predetermine the vector of development of medicine in the future. The foundations of knowledge gained over the period of more than 70 years of scientific activity of Professor R.M. Bavsky are reflected in promising areas of cardiology research using computer technologies - such as Cardiometry technologies.
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Другой
The present issue of our journal is of very special nature. We are constantly analyzing not only the readers’ focus of interest to the publications in our journal, but we are also tracing how cardiometry as a new science is realized by medical doctors and how they apply it in their practice. Undoubtedly, the mathematical fundamentals of hemodynamics are very difficult to understand not only by doctors, but even by mathematicians. Therefore, we have decided to collect in the first section of the present issue all the basic, previously published, mathematical concepts of hemodynamics as a complete collection part, in order to provide our readers with a convenient reference form. We think that this is an absolutely reasonable idea, since our journal always offers a thematic outline philosophy. We can see that it plays an important role in attracting the readers’ attention all over the world.
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Статья научная
In the present article the relevance of using DSS under the current conditions for image recognition and, as a more specific application, for the purpose of additional assistance rendered to medical experts (radiologists) in their decision-making and preparing findings upon assessment of X-ray images is considered. The paper analyzes the requirements for some expert DSS and their main characteristics that they should have; considered and selected is the necessary software for making rapid diagnoses of diseases of the thorax. All these modern requirements and characteristics are met by the Deep Learning Studio (DLS) software, which allows using deep convolutional neural network Inception V3 to teach this network and further obtain optimal results in the recognition and diagnosis of diseases of the thorax by assessing X-ray images. As a result of this study, a ready-made DSS intended for use by medical institutions for additional assistance to radiologists to prepare findings according to X-ray images has been obtained.
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Dendritic cells and their role in cancer immunotherapy
Статья
Cytotoxic CD8+ T lymphocytes (CD8+ CTLs) are key effector cells, which recognize and kill tumor cells, and are therefore preferred targets for improved cancer immunotherapy.
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Dental status of patients with cardiovascular diseases and diabetes mellitus
Статья научная
This article discusses some regional features of the structure of dental morbidity in patients with cardiovascular diseases and diabetes mellitus. The relationship between these diseases is shown. It is stated that there is a lack of awareness of the existing dentition diseases in this sort of patients
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Depression: a predictor of coronary heart disease in Saudi Arabia
Статья научная
Aims and Objectives: This research study mainly deals to evaluate the effect of depression in coronary heart disease patients. Background: Depression is one of the common comorbidity among patients presented with acute coronary syndrome or those with major cardiovascular event. Depression has been independently associated or lead to acute cardiac events in patients. Method: The study was conducted from three months followed-up patients with recent diagnosed coronary heart disease and they getting treatment from cardiac centres “Armed Forces Hospitals. Depression was evaluated by using 17-item Hamilton Rating Scale and the cardiac outcome was assessed clinically by echo parameters and cardiac biomarkers such as C-reactive Protein. The data were analysis by SPSS version 23. Results: In this study 83 patients were part of this research. The patients had been picked up from range 18-65 year in which mostly patients were male (75%) than female (25%). Among 83 coronary heart disease patients 29.5% were suffering from depression while 19.5% were on severity. The deterioration factor was significantly influence by depression and smoking. Conclusion: Depression has a great impact on deterioration of the cardiac outcomes. It can serve as a predictive variable for future cardiological morbidity and mortality.
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Статья научная
Reduction of maternal and infant mortality rates has been recognised as one of the important goals of this century. Both coverage improvement and inequity reduction have been set up as millennium targets. Despite the availability of effective interventions, maternal and child healthcare conditions are not improving in developing countries because of inefficiently functioning health systems. Knowledge generation about behaviors of health system building blocks on the implementation of several healthcare interventions will help policymakers to design situation- specific and strategic interventions. A decision support system has been devised incorporating data mining algorithms which would help to understand the condition of maternal and child healthcare indicators; educational, socio, and economic situations; healthcare status; and healthcare service blocks and their relationships with each other. In this paper, the design of the DSS has been discussed elaborately. To enhance a system- wide understanding of the healthcare system, all healthcare- related factors have been incorporated into this system. Three knowledge generation modules have been prepared by utilizing different visualization and data mining algorithms.
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Detection MEC a gene and susceptibity some various antibiotic of Staphlococcus aureus
Статья научная
Through the study conducted in Najaf Governorate, bacterial samples were collected from different places. We notice during the study that the results were divided into two parts. The first was that the antibiotic Vancomycin had the highest rate of sensi-tivity to most of the bacterial samples, and this can be explained as follows. The bacterial isolates do not possess resistance genes or phenotypic factors that are highly effective against this antibi-otic. Therefore, the effect of the antibiotic was significant on most of the bacterial isolates. At the same time, some bacterial isolates showed resistance to the antibiotic Vancomycin. This can be ex-plained by the fact that these isolates possessed resistance genes or Phenotypic factors are resistant to this antibiotic, so resistance has been shown in some bacterial isolates. As for the second section, we note that the bacterial isolates had a very high rate of resistance to all other types of anti-biotics. This can be explained by the fact that these bacterial isolates possessed resistance genes, virulence factors, or both, which made them significantly more resistant to this antibiotic... and through review. Based on other research at the level of Iraq, as well as other countries, we notice that Staphylococcus au-reus bacteria is constantly evolving in resistance to antibiotics. We also note that the places where samples are collected have a role in resistance and sensitivity to antibiotics
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Статья научная
At present, there are some scattered evidence data pertaining to the use of an adaptive technique of radiotherapy in treatment of malignant glial tumors of the brain. Our evidence data obtained in MRI in the course of treatment show that the initial treatment plan may become irrelevant due to some changes observed in the tumor configuration. In its turn, it bears witness to the topicality of developing and introducing adaptive methods and techniques in the brain tumor treatment, which are capable to increase efficacy and tolerability in patients with primary malignant tumors of the brain. Aim. Our aim has been to develop an adaptive stereotactic method of radiotherapy in treatment of primary malignant brain tumors, which shall be capable to increase efficacy and tolerability of radiation therapy as well as reduce radiation dose to normal structures in the brain. Materials and methods. Our method has been elaborated with recruiting a group of 10 patients diagnosed with primary glioblastoma G IV, which have received specialized treatment at the National Medical Research Centre for Oncology at the Ministry of Health, the Russian Federation, in the period 2021-2022. The average age of the above patients is 43,4 years. All patients have undergone microsurgery covering the total resection of the tumor (3 patients) and subtotal removal of the malignant tumor (7 patients). The average time interval between the surgery and radiotherapy is 32,5 days. Before treatment, an intravenous contrast enhancement MRI of the brain with an axial pitch of 1 mm has been conducted employing the contrast T1, contrast-free T1 and T2 FLAIR modes. Planning of radiotherapy for this sort of patients has been carried out employing BrainLab Elements и Varian Medical Systems Eclipse. The CTV was defined as a 2,0 cm margin around GTV with an anatomical correction. The CTV-to-PTV margin was 0,1 cm. Doses have been administered as follows: a single dose of 2 Gy up to a total dose of 60 Gy in 30 fractions. The brain has been MRI-scanned in all patients with the use of intravenously introduced contrast agents with an axial pitch of 1 mm employing enhanced contrast/contrast-free T1 sequences and T2 FLAIR to redefine the radiotherapy targets (GTV, CTV, PTV). At fraction 30 we have completed MRI in order to estimate the treatment outcome. In the average, the radiotherapy course has taken 42-45 days, holidays included. For the purpose of the radiation therapy, used have been the Novalis Tx Varian Tx linear accelerator of kinetic energy of the beam of 6 MeV. Results We have developed our own adaptive stereotactic method of radiotherapy to treat the primary malignant glial tumors in the brain, which is capable of tracing the configuration of the post-surgery cavity, the residual tumor and the brain structures in the course of radiotherapy and adapting the therapy plan thereto that makes possible to reduce tissue volumes exposed to radiation due to a decrease in the tumoral and peritumoral volumes of the tumor and post-operative cavity. Conclusion. Our analysis has shown that in the course of radiotherapy some anatomical changes in the tumor configuration are found. An adaptive approach applied to radiation therapy allows monitoring the above changing volumes and correcting the treatment plan.
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Development of an experimental model of tumor growth under hypothyroidism
Статья научная
Aim. Our aim has been to develop an experimental model of the tumor growth against the background of hypothyroidism in rats of both genders in order to study possible influence made by hypothyroidism on progression of malignant tumors of various histological types. Materials and methods. In our studies we have used 100 outbred albino rats of both genders, with an individual body mass of 150-180 g. The female rats (n=30) and the male rats (n=30) have received Mercazolil at a day dosage of 2,5 mg/100g of the body weight for 30 days. After hypothyroidism in the treated rodents had been confirmed, one group of them (15 females and 15 males) were subcutaneously inoculated with the Guerin's carcinoma cells, and another group (covering other 15 females and other 15 males) has been undergone to transplantation of the Sarcoma 45 cells. The reference group has included the rats of both genders with subcutaneously inoculated the Guerin's carcinoma cells (n=10 females and n=10 males) and Sarcoma 45 cells (n=10 females and n=10 males), but without reproduction of the hypothyroidism model. Upon expiration of one month, within the 3 day period, we have estimated with a radioisotope analysis (RIA) standard assay kits (Immunotech, Czekh Republic) the levels of the thyroid hormones in blood of the tested animals as follows: Triiodothyronine (T3) (pM/L), total Thyroxine (T4) (pM/L) and Thyroid-Stimulating Hormon (TSH) (μU/mL). The obtained data have been processed with Statistica 10.0. Results. Upon the treatment with Mercazolil, we have found in the females a decrease by a factor of 7,3 in the total level of Thyroxine and an increase by a factor 1,6 in the TSH level (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Development of modern technology for obtaining tinctures with sedative effect
Статья научная
The aim of this work was to experimentally select the optimal conditions for obtaining a tincture with an effective sedative effect consisting of a mixture of common motherwort grass, medicinal lemon balm and nettle leaves in a ratio of (1:1:1) and the development of quality criteria for the finished product. The influence of the concentration of the extractant, the ratio of raw materials to extractant, the multiplicity of extraction and the mode of infusion with the use of auxiliary technologies (ultrasound treatment) on the yield of biologically active substances from the raw materials was studied. It has been established that the most acceptable way to obtain this tincture is maceration using ultrasound. This method allows us to obtain a tincture with a high yield of flavonoids with the minimum time used.
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