Original research. Рубрика в журнале - Cardiometry
Статья научная
The article examines the importance and relevance of interdis-ciplinary functional diagnostics for the detection of gynecolog-ical diseases with an endocrine basis against the background of anemia in women. The necessity of an integrated approach to diagnosis is sub-stantiated, combining methods from various medical fields to identify links between the endocrine system, gynecological pa-thologies and anemia. The results of the work emphasize the importance of an interdisciplinary approach for more accurate diagnosis and optimization of treatment of gynecological pa-thologies against the background of anemia, contributing to improving the quality of life of patients. This article examines a practical example of the application of interdisciplinary functional diagnostics for the detection of ane-mia against the background of endocrine pathologies in preg-nant women. Research on the health status of pregnant women is becoming increasingly relevant in the context of ensuring optimal condi-tions for fetal development and maternal health. One of the key problems requiring attention is iron deficiency anemia and its connection with thyroid function in pregnant women. Under-standing the relationship between these conditions is essential for effective pregnancy management and prevention of com-plications in both mother and fetus. In this study, attention is paid to the study of the relationship between serum ferritin levels, thyroid hormones and the pres-ence of iron deficiency in pregnant women in early pregnancy. The results of the study reviewed in this article confirmed the existence of an inverse correlation between serum ferritin levels and the level of one of the thyroid hormones, which indicates a possible relationship between iron deficiency and thyroid function in pregnant women. These findings are important to the medical community, providing a framework for developing strategies for the diagnosis and management of pregnancy, taking into account the interaction between iron deficiency and thyroid function. The results of the study can become a starting point for new research approaches and contribute to the devel-opment of more effective methods of supporting the health of pregnant women. This article also focuses on the development of anemia in women in the menopausal period.
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Pyelonephritis is a serious disease that is widespread in Iraq and is mostly caused by Gram-negative bacteria, which are highly contagious and can spread from an infected person to others. The aim of this article was to evaluate the immunomodulatory role of Monocyte chemotactic protein-3 (MCP3) in the blood serum of patients with acute pyelonephritis and chronic pyelonephritis. A group of patients suspected of having nephritis were sampled in Najaf city, Iraq. Clinical and biochemical tests were performed to confirm their infection. Where 30 patients had acute pyelonephritis and 30 patients had chronic pyelonephritis, in addition to 29 healthy people who were considered control. MPC-3 was measured in the serum of the affected person using ELISA technology. MPC3 levels were significantly elevated (P
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The low efficacy of ongoing conventional therapy and a significant decrease in the quality of life in patients with reconstructive plastic surgery (RPO) on the pelvic organs (PO) due to tubal-peritoneal infertility (TPI) and chronic nonspecific salpingo-oophoritis (CNSO) requires searching for new, promising methods of non-drug treatment, in particular, taking into account the regional characteristics of the Republic of North Ossetia-Alania and its natural resources. One of the main ways to increase the efficacy and intensify the treatment of this category of patients is the use of natural factors, namely, sulfide waters of the local Redant-4 deposit, which have a number of anti-inflammatory effects. Purpose of the study is to assess the role of non-drug technologies using magnetic infrared-laser therapy and balneological factors of the local deposit in the rehabilitation of the reproductive function in patients undergoing reconstructive plastic surgery due to TPI and CNSO. Material and methods. 235 women with impaired reproductive function, who underwent laparoscopic reconstructive plastic surgery on the pelvic organs (RPO on PO) due to tubal-peritoneal infertility (TPI) and CNSO, whose average age was 28 + 7 years, were examined. 2 groups were formed by the method of blind sampling: the main group consisted of 139 women with RPO on the pelvic organs due to TPI and CNSO, who, along with conventional therapy, received magnetic IR-laser therapy and had hydrogen sulfide baths; the comparison group included 96 women with RPO on PO due to TPI and CNSO, whose treatment was carried out by conventional methods of drug therapy. The conventional treatment included along with antibiotic therapy the use of ecological adaptogens (aloe, apilac), immune modulators (polyoxidonium), vitamin therapy (vitamin E 100 mg / day for 3 months and B vitamins), drugs to eliminate disorders in the intestinal and vaginal flora (antifungal agents: fluconazole, tergynan, acylact for 7-14 days). The patients of the studied groups were observed before their treatment and 1-12 months after the treatment. All patients underwent a clinical and functional examination. Statistical processing of the material was carried out using the package Statistica for Windows. Results. A control examination of patients of both groups showed a more pronounced positive effect on the course of a number of clinical symptoms in the postoperative period in the main group of patients who received magnetic IR laser therapy and had sulfide baths of the North Ossetian deposit in the complex of therapy. As a result of the physiotherapy treatment, the pain syndrome was eliminated in 107 of 139 patients (77%) who complained of pain before their treatment. A decrease in pelvic pain after the course of treatment was noted in 46 patients (33%). It should be noted that in the majority of patients 94 (68%), who received sulfide balneotherapy, a decrease in the formation of repeated adhesions of the pelvis was revealed during the procedures, the effectiveness of the regression of the adhesive process was found throughout the observation. It was detected that against the background of the proposed non-drug technology in the rehabilitation treatment of patients with RPO on PO due to TPI and CNSO, a significant increase in the effectiveness of treatment of this pathology (89%), improvement in the quality of life of patients as well as restoration of fertility has been achieved. Conclusions. The use of the method of sulfide balneotherapy in patients with RPO on PO due to TPI and CNSO allows shortening the duration of their next treatment and achieving the maintenance of positive dynamics and duration of regression of the adhesive process of the pelvis.
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The role of pacemaker algorithms in preventing atrial fibrillation progression
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Background: Unnecessaryright ventricular (RV) pacing leads to cardiac dyssynchrony and increases the risk of developing permanent atrial fibrillation. Minimizing RV pacing by specefic algorithms decreases the AF risk. Aim and objectives: Our objective was to study the effect of pacemaker algorithms on atrial fibrillation progression. Subjects and Methods: Patients with dual chamber (group A) and single chamber (group B)pacemakers were included in the study. Patients with history of AF at the time of pacemaker implantation were not included in the study. The relation between pacemaker parameters and AF development was monitored. Result: Group A showed that RV pacing percentage had high significance for developing AF with P value P
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At present, control of properties of biological membranes as targets of magnetic field applications within a living cell is the subject of considerable discussion in the scientific community. Experimental studies carried out by us demonstrate that ULF MF has an access to the most important mechanisms of tumor growth. The most likely mechanism among them is that responsible for the processes of free-radicals oxidation. Therefore, our research work was aimed at studies of influences of ULF MF on indicators of the anti-oxidation system in blood plasma and blood cells in rats in the chemically induced cancerogenesis. Our experimental studies were performed in 45 outbred albino male rats having a body mass from 160 to 180 g. The state of the anti-peroxidation protection of cell membranes was assessed by indicators of the fermentation subsystem of AOS (catalase, TPA, SOD), and the state of the non-fermentive subsystem of AOS was estimated by indicators of the concentrations of vitamins A and E in blood serum...
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Aims The aim of our research work was to investigate the state of the lipid peroxidation system - the antioxidant protection system (LPO-AOS) in heart tissue in rats received either Doxorubicin alone or in combination with Preductal premedication. Materials and methods Our experimental studies were carried out in mature male albino rats from outbread stocks (the cohort covered 50 animals) with an individual body mass from 150 to 160 g. The cohort included the following groups of the rats: the reference group covered 10 intact animals; group 1 (20 rats) received dosage of Doxorubicin of 2mg/kg, five times, up to a cumulative dose of 10 mg/kg; group 2 (20 animals) medicated as follows: the 5-day introduction of Preductal with dosage of 35 mg/kg followed by Doxorubicin medication according to the same schedule used in group 1. MDA, levels of the A & E vitamins, SOD and catalase activity, Total Peroxidase Activity (TPA), the ratios E/A, SOD/TPA and SOD/catalase were assessed in heart tissue...
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Статья научная
Aims The aim hereof is to study the activity of cathepsin D (CatD), alkaline phosphatase (ALP) and acid phosphatase (AP), the antitryptic activity (ATA) of acid-stable inhibitors (ASI) in rats in heart tissue and its draining lymphocytes under introduction of Doxorubicin and protection with Trimetazidine.
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The state of the cardiovascular system in women during pregnancy
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The work is devoted to the study of the impact of pregnancy on the state of the cardiovascular system in women. The process of pregnancy is accompanied by significant changes in the rhythm of the heart performance and blood pressure, and the duration of the ECG waves and segments are not significantly fluctuated. The heart rhythm, gradually increasing, reaches its maximum value of 87.3 beats per minute (P
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Celiac disease is an autoimmune disorder triggered by the ingestion of gluten in genetically susceptible individuals. The current study aimed to compare the levels of these antibodies in celiac disease patients on active gluten-containing diets and those on gluten-free diets to demonstrate the ability to get rid of Celiac Disease by Gluten-Free Diet. The study involved 100 participants, divided into 60 CD patients and 40 controls, where all participant match in age and gender. The patient group was further divided into two subgroups 40 active celiac and 20 GFD. Blood samples were obtained from all participants, and levels of anti-tTG and anti-gliadin antibodies were using Enzyme-Linked Immunosorbent Assay (ELISA) technology. The results showed The F test indicated a significant difference in the levels of anti-tTG and anti-gliadin antibodies between the active group (G1) and the diet group (G2) in comparison to the control group (G3), with a p-value less than 0.001. Upon conducting a deeper analysis using the least significant difference (LSD) on on anti-tTG IgA and IgG indicate that there are no significant differences between the patient groups G1 and G2, as evidenced by p-values of 0.120 for IgA. However, a significant difference was observed between G1 and G2 for IgG, with a p-value of 0.018. When comparing G1 with G3, and G2 with G3, significant differences were observed, with p-values less than 0.001. In the case of anti-gliadin IgA and IgG, the LSD test revealed a highly significant difference between G1 and G2, as indicated by a p-value less than 0.001. However, no significant differences were found between G1 and G3, with p-values of 0.499 for IgA and 0.110 for IgG. A highly significant difference was none the less observed between G2 and G3, with a p-value less than 0.001.In conclusion, This study highlights the importance of dietary adherence in celiac disease management. Patients on gluten-free diets had significantly lower levels of anti-TG and anti-gliadin antibodies, indicating better control of the autoimmune response. Monitoring these antibody levels can be a valuable tool in assessing the effectiveness of dietary interventions in celiac disease patients.
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The article presents some results of an interdisciplinary study aimed at clarifying the conditions for the use of cardiometric and electrodermal indicators of human activity as a means of attesting to visual online content. To record personal reactions to selected visual objects, the authors use a range of tools, including computer cardiometers, portable eye trackers and polygraphs of various modifications. To achieve this goal, the authors conducted a multi-level test of Russian youth using current political symbols and images from online communities and other social media platforms. The results of the study prove the high efficiency of using cardio-oculometric detection combined with automatic recording of electrodermal activity to obtain reliable information about affective and rational-logical features of perception of visual online content. The study also extends the research understanding of the specifics of using this combination of diagnostic tools in different conditions.
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The article presents experimental data confirming an assump-tion that an independent performance referring to the selection and ranking of visual stimuli by respondents allows not only to identify, but also to build a hierarchy of regulators of social be-havior of each individual. It is shown that this kind of diagnos-tics also makes possible to determine the prevailing moral and ethical regulators in behavior in a particular social group, which can easily be represented as the poles of semantic differentials. It is noted that an important feature of this type of diagnostics is the subject-genetic nature of the procedures performed, owing to which each respondent begins to more clearly realize his/her life priorities and expands his/her readiness for vitally important decision-making.
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Current guidelines recommend that patients with ST-elevation myocardial infarction (STEMI) receive primary percutaneous coronary intervention (PCI) with a door-to-balloon (D2B) time of 90 minutes. This time frame has been difficult to achieve in developing countries. We aimed to test the hypothesis that using WhatsApp for inter-hospital transfer in STEMI primary PCI would result in shorter D2B time through avoiding emergency department (ED) waiting.
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To study about the relation between oxygen delivery and hemodynamics during cardiopulmonary bypass
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The study put forth the relation between oxygen delivery and hemodynamics during cardiopulmonary bypass. The study was performed on 26 patients of either sex have age > 10 years and who underwent elective open-heart surgery from June 2017 - May 2018 in Sri Ramachandra Medical College & Research Institute. The patients with valvular heart diseases associated with other cardiac lesions like Intra cardiac shunts (ASD, VSD etc.) and Coronary artery disease (CABG) are excluded in the study. It examined the relationships among VO2, hemodynamics & DO2 during clinical perfusion, namely throughout moderately hypothermic CPB using a non-pulsatile roller pump while managing the alpha-stat acid-base with adults. The results revealed a linear relationship between VO2 and DO2, demonstrating that higher levels of delivery can perfuse and collect additional vascular beds throughout the CPB. Under bodily tissue perfusion, higher deliveries are advised to be avoided. The oxygen demand decreases by 7% for every 1OC decline in patient temperature.
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Trigeminy electrocardiogram spectral characteristics study
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This paper presents the results of a study in which the method of ECG decomposition in the time domain (DMTD) was applied, followed by a spectral analysis. A digital signal with trigeminy of the first lead of a standard electrocardiograph was processed. Using digital filtering in time domain, the electrocardiogram (ECG) was cleared of noise, what results the reduction of spurious components by 10-20%. To represent and classify the frequency characteristics throughout the entire processed cardiac signal, the QRS complexes were removed, P and T waves were left unchanged. Due to considerable influence on the spectral analysis sharp peaks of the ECG signal with small characteristic times of the leading and trailing edges, the obtained result differs considerably from the sum of the harmonic components of the smooth part of the signal. The spectral processing reveals peaks at multiple frequencies, 1.6 Hz, 3.2 Hz, 4.7 Hz, corresponding to a smooth function of P and T waves before the appearance of extra systoles. Based on the obtained data, the frequencies corresponding to the peaks of the cardiogram with a stable sinus rhythm were identified. The acquired data represent regular harmonics, which allow adequate quantitative ECG analysis.
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Understanding e-sports industry and impact of COVID-19 on it: a review of literature
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COVID-19 brought the whole world to a halt suddenly and forced it to go on social distancing & lockdown. COVID-19 has impacted every industry worldwide differently and mostly negatively, so we wanted to look at its impact on the ‘esports industry,' especially in the Indian context. To understand the impact, we did a detailed literature review of academic papers, articles, industry reports to determine the current trend and predict possibility in the future. Our findings indicate that although the industry is facing issues, COVID-19 actually might have helped the esports industry in the long term and expedite its progress among the young generation. Once everything was done, we analyzed the complete literature review, and based on that; we listed out our findings, and based on our findings, we did a final evaluation. We reviewed the existing work of academicians, business reports, industry reports, trends captured by news/media organizations, and the current state of video games to find the trends & reasons which could help us solve our question.
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Use of cardiometry and oculography in concealed information detection
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Aims The article presents the results of an experimental study on the use of cardiometry and oculography to detect concealed information. It has been shown that a complex assessment of the person's emotional-cognitive state based on cardiometric and oculographic recording of reactions to specially selected stimulus material of visual and audial modality can be successfully used in concealed information detection. Materials and methods We used the Cardiocode single-lead cardiograph and the GP-3 eyetracker as the instrumental basis for testing the hypothesis of the study. We have selected the above devices taking into account the previous analysis of their functional features and the basic possibility to use both devices together, the availability of the devices for a wide range of researchers and practitioners. To prove the hypothesis of the study, a complete set of the relevant subtests has been developed that implied both verbal (tests No. 1-3) and visual graphic presentation of stimulus material (tests No...
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Use of sentiment analysis in social media campaign design and analysis
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Sentiment Analysis is the process by which opinions are defined and categorized as positive, neutral, or negative in a given piece of text. It is a vital part of every strategy for tracking social media. It helps to understand what someone is thinking behind a social media post. Knowing the emotion will provide valuable background for the businesses to move further and react. Over the last decade, numerous studies have been carried out on how businesses can use Sentiment Analysis to understand and quantify the feelings of their consumers about their brand, products, and services. An in-depth analysis of the existing empirical literature on SA regarding social media campaigns is provided using a systematic review of the literature. This paper presents the findings according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA). The aim is to create a resource of the methods and techniques used in the studies to assist both researchers and academia. We subsequently identified the corpus trends, challenges, and implications. We suggested avenues for further research in the application of SA in social media campaign design and analysis.
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Today, among the urgent tasks facing the pharmaceutical science of the Republic of Uzbekistan is the study of introduced medicinal plants. Of the promising plants Erva woolly - Aerva lanata Juss of the amaranth family (Amaranthaceae) deserves special attention. A perennial or biennial herbaceous plant grows in many countries of Africa, Saudi Arabia, India, Indonesia, etc. For the first time, Aerva lanata Juss. was introduced on the territory of the former USSR by the Transcaucasian zonal experimental station VILR (Kobuletti) in the mid-70s, then in Ukraine, Uzbekistan and Kazakhstan. Aerva lanata is a dioecious plant. The flowers of A. lanata are nectariferous. Pollination of Erva woolly occurs under the influence of gravity inside the flower, wind, insects and rainwater. Erva woolly with more than one pollination and seed dispersal mode is able to invade a variety of habitats with different environmental conditions and grow as widespread weeds. Among other Aerva species, A. lanata cultivar has a wide range of pharmacological activities such as sedative, antiulcer, antiasthma, antidiarrheal, antioxidant, antihyperglycemic, antimalarial, hypolipidemic and other activities. It is used as a diuretic, for acute kidney damage, as well as for ulcerative wounds, rheumatism. Given the availability of the raw material base necessary to meet the possible growth in consumer demand and its widespread use in traditional and scientific medicine to create effective, low-toxic drugs intended for the prevention and treatment of diseases of the urinary system, Aerva lanata Juss L. was chosen as the object of research. An important stage in the standardization of the final product is the quality control of the technological process and the raw materials entering the production to obtain the finished product. Particular attention is paid to the method of quantitative determination of one of the active substances or groups of biologically active substances that affect the therapeutic effect of finished pharmaceutical products. It is known that the quantitative determination of the active substance is carried out by its extraction from plant materials. In this regard, the problem arises - finding the optimal conditions for the process of extracting the active substance. In view of this, it becomes necessary to conduct research to determine the optimal conditions for the extraction process. The objective of the research: the use of the mathematical planning method of the experiment for the complete extraction of flavonoids from the herb Aerva lanata. To achieve this objective, the following tasks were defined: - selection of the mathematical planning method of the experiment; - selection of method for quantitative determination of flavonoids amount; - statistical analysis of the obtained results. Optimization of the process of extracting the amount of flavonoids from the herb of Aerva lanata, which is predominant in its raw materials, was carried out using the method of mathematical planning of experiments by Box and Wilson. The optimization problem was reduced to determining the values of technological parameters that ensure the maximum yield of total flavonoids from the plant. As an optimization parameter, Y was taken - the content of the sum of flavonoids in the extract, in % of its content in the raw material. Conclusion. This article presents the results of modeling and optimization of the process of obtaining the sum of flavonoids from the herb Aerva lanata Juss. L. A comprehensive quantitative assessment of the influence of three experimental factors (alcohol concentration, hydromodulus and extraction time) on the yield of the total flavonoids was carried out using the method of mathematical planning of the Box-Wilson experiment. The objective was achieved by building a mathematical model based on the first order regression equation: Y=1.20+0.185X1+0.091X2+0.111X3 The adequacy of this process is shown, a mathematical model and parametric identification of this model are presented. As a result of the statistical analysis of the obtained data, the following optimal conditions for the process of extracting the amount of flavonoids from the herb of Aerva lanata were revealed in the quantitative analysis of raw materials: alcohol concentration - 50%; hydromodule - 1:60; extraction time - 30 min. The maximum yield of the sum of flavonoids was 1.52% by weight of dry raw materials. The resulting mathematical model of the extraction process will allow further optimization of the extraction of compounds of natural origin, taking into account the quantitative influence of each factor.
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Aims The paper offers some results from our experimental studies to determine validity of a complex performance fingerprint: the Baevsky stress index used to assess effectiveness of training programs: training sessions targeted at formation of phsychosomatic self-regulation skills and visual & verbal practical training course aimed at development of emotional intelligence. Materials and methods In order to determine the criterion-related validity of cardiometric assessments of training results, we have organized training sessions addressing scheduled staged formation of the self-regulation skills. Before the training sessions and after them, our training participants have been instructed to perform a set of three tasks, covering the following: - to imagine a calming video clip; - to imagine some TV news reporting various dramatic incidents, emergencies, calamities etc. - to generate self-relaxation, to perform the task to get relaxed and initiated or induced an emotional balance...
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Workplace motivation and job satisfaction among generation Y in India
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Employee work motivation and job satisfaction are dynamic and demanding goals for a business. It has been much more daunting in today’s dynamic workforce. A business is a wonderful workspace that serves the expectations of each employee and motivates each one to achieve its objectives. The present research illustrates the desires and aspirations of various employees regarding work encouragement and satisfaction from the organization. The focus is on understanding specific characteristics, needs, and expectations of Generation Y, which in today’s context are considered to be critical. There is also an emphasis on learning how and what motivates workers in Generation Y. In addition, racial and geographic diversity is often taken into consideration in this report. The company that recognizes the requirements and can help its workers improve is producing greater performance. In this analysis, a technique of the interview is used. A group of 254 workers from different backgrounds and ages is evaluated for the quantitative model. Any variables suggesting relevant HR behaviors are taken from earlier research in this report. In the study of human personal variations in organizational efficiency, the “locus of influence” aspect is often taken.
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