Original research. Рубрика в журнале - Cardiometry
Статья научная
True experimental research study was conducted at Haemodialysis’ Unit at Sree Balaji Medical College and Hospital among End stage Kidney disorder patients receiving haemodialysis to determine the efficiency of ROM exercise on muscle cramps, using purposive sampling technique 12 patients for control group and 12 from experimental were selected for the study based on inclusion criteria .The experimental group were received intradialytic ROM exercise and determined the Muscle cramps by using PENNS SPASM SCALE the findings were In pretest as well as in post test, there is no major linking of experiment and control group except severity. Pre test calculated value for severity, interference and frequency c2=0.17 p=0.67, c2=0.68p=0.41, c2=0.22 p=0.90 respectively. The calculated post test value for severity was c2=4.19 p=0.05 found to be significant. Association between the demographic variables with experimental group shows the Monthly income and supportive system was having the relationship among muscle spasm and chosen demographic variables.
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The study aimed to estimate the levels of cytokines as biomark-ers that play an essential role in the progress or suppression of disease for lung cancer as well as to regulate the immunologi-cal response of patients with lung cancer. The specimens were taken from the tumoral center/Imam Hussein Hospital/Karbala, and Middle Euphrates Cancer Center/Najaf during the period from (November 2023 to the end of January 2024), where 100 blood samples were collected from patients 65 males and 35 females respectively who suffered from lung cancer and then separated of blood samples to obtain serum and to evaluate the levels of IL-17 and IL-10 by centrifugation to obtain of the serum and it was used to evaluate the levels of IL-17and IL-10 via the using of Enzyme-Linked Immunosorbent Assay (ELISA) as well as it was collected 30 samples as the healthy control group and all collected samples of patients and healthy group with aged around 30 to 78 years, the cases of all patients be-long to the type of Non-small carcinoma lung cancer and were divided based on stages as 40(33.3%) of stages I and II, 32 (26.6%) of stage III, and 48(40%) for stage IV. The current study showed the serum levels of IL-17 and IL-10 in stage IV lung can-cer patients (0.5268 ± 0.01679) pg/ml were higher significantly (p≤ 0.05) compared with stage III (0.3503 ± 0.01853)pg/ml and stage I-II (0.2951 ± 0.01142)pg/ml.
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Level of delirium and its contributing factor among patients in ICU
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Background: Delirium is an acute state of confusion characterized by a rapid onset, usually within hours to days, with changes in consciousness and cognitive changes. Delirium may also present as a form of agitation in intensive care patients. Delirium can affect up to 80% of patients in intensive care units and increase their length of stay and cost of hospitalization. Objectives: The main aim of the study is to evaluate the level of Delirium and its contributing factors among patients in intensive care unit. Methods: A descriptive study design was adopted for the study with 60 samples that met the inclusion criteria and were selected using convenience sampling technique. Data for demographic variables were collected using multiple-choice questionnaires, followed by assessment of delirium using the Confusion Assessment Method (CAM) scale. Results: 20%) had mild delirium, 13 samples (21.7%) of moderate delirium and 13 samples (21.7%) of severe delirium. Regarding the demographic variables of delirium, diabetes rapidly had a statistically significant association with the degree of delirium in ICU patients at p
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Leveraging learning interventions for talent development: an inductive approach
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Purpose: The paper aims to focus on the question “How can we leverage learning interventions for talent development?” The rise in the need for learning and development for employees has become a priority and a primary reason for job dissatisfaction. Learning and development initiatives are believed to build the required through training campaigns, competencies, and exposure to critical experiences where employees across different bands and streams can be nudged to attend training, enhance their skills, and increase engagement. For an organization to have a learning culture, the most important thing is employee awareness concerning their learning and how their learning is benefiting the business and aligning the individual’s needs to organizational goals. It is usually found that because of time constraints and other factors, employees do not pay much attention to up skill themselves, which calls for a systematic framework to nudge them for inculcating a learning environment. Design/Methodology/Approach - An explorative, qualitative study based on focus groups designed. Findings: Due to time constraints and other factors, employees do not pay much attention to up skill themselves, which calls for a systematic framework to nudge them for inculcating the learning environment. Limitations: Based on the findings, few priority aspects may be crucial to the learning environment. Originality/Value: This paper serves the purpose of explaining the necessity of learning intervention techniques for talent development.
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Статья научная
Aims The observed experimental and natural phenomenon of cyclone-anticyclone vortex asymmetry implies that a relatively more stable and showing a longer life, as well as a relatively more intense mode of rotation with an anticyclonic circulation direction (opposite to the direction of rotation of the medium as a whole) is realized as compared with an oppositely directed rotation of the cyclonic vortex mode. Until now, however, it was not a success to identify a universal triggering mechanism responsible for the formation of the corresponding breaking of chiral vortex symmetry. Materials and methods In this paper we reveal the said linear universal instability mechanism of breaking of chiral symmetry in the sign of vortex circulation in the rotating medium in the presence of linear Eckman friction. Results Obtained is a condition for the linear dissipative - centrifugal instability (DCI), which leads (only when considering the external linear Eckman friction for an abovethreshold value of rotation frequency of the underlying boundary surface of fluid) to the breaking of chiral symmetry in the Lagrangian fluid particle dynamics and the corresponding realization of the cyclone-anticyclone vortex asymmetry...
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Lipstick color suggested using hybrid hidden Markov model
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In today’s lifestyle, facial makeup plays an important role in enhancing visual attractiveness a nd boosting one’s self-esteem. Makeup is known as the second skin of the women, and that too lipstick is a soul of the makeup. According to a survey, an average urban woman spends almost one year and three months of her life just wearing makeup. This much of the time is due to decision-making and choosing the best makeup style that would fit a particular age, skin complexion, profession, and occasion, requiring high imagination and full art. Many makeup recommendations systems exist, but no solitary system has existed to recommend a lipstick color properly to solve this problem computationally. Therefore, as a tiny step towards helping women save their time in decision-making, the proposed model puts forward an idea of a hybrid recommendation model for lipsticks alone. This proposed methodology uses a hidden Markov model to unleash the possible color of the lipsticks based on the given attributes. The collaborative filtering system catalyzes the process to recommend the best lipstick colors using a hybrid recommendation model.
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Статья научная
Introduction: Hypertension is found to be the prime cause of death worldwide in spite of a number of available treatments which suggests that there is a need of discovering new lead molecules that would be more effective to treat cardiovascular disease (CVD). Liriodendrin, the lignan phytoconstituent possesses potential pharmacological effects. Literature survey suggests that liriodendrin could be effective in mitigating hypertension considering its structural similarity with reported cardiovascular protective drugs. Hence liriodendrin is investigated to reveal its mechanism of actions to support its antihypertensive property. Methods: Hypertension was induced in male wistar rats with DOCA salt. Hypertensive rats were treated with liriodendrin for 4 weeks. Blood pressure, heart rate, body weight, lipid profile, serum nitrite levels, vascular reactivity to various catecholamines, in-vitro calcium channel blocking assays, antioxidant assay, determination of aortic calcium level, endothelial function, expression of eNOS analysis were studied. Result: Liriodendrin was found safe orally up to 2000 mg/kg. It showed a significant decrease in heart rate, blood pressure and mean arterial pressure. In-vitro study on the isolated rat aorta revealed the calcium channel blocking potential of liriodendrin. Vascular reactivity to various catecholamines was normalized. Vascular endothelium was significantly protected by the enhanced release of nitric oxide and eNOS expression by the western blot technique. Oxidative stress was also significantly reduced. Conclusion: Liriodendrin was found to be beneficial in hypertension as it produced vasorelaxation by blocking calcium channels, enhancing nitric oxide release, and reducing oxidative stress. Thus, liriodendrin may be useful to relieve hypertension and cardiovascular complications.
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MRI brain image classification using linear vector quantization classifier
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The metastases cancer other than the lifestyle-related or environmental related no known facts for the brain tumors. Only factors that may cause brain tumors might be the exposure to high ionizing radiation and a family history of any brain disease also increase brain cancer risk. The cancerous brain is a brain disorder that shapes masses in cells called tumors. The early diagnosis of brain cancer using the Magnetic Resonance Imaging (MRI) scan image for cancer disease is required to reduce the mortality rate. Dual-Tree Mband Wavelet Transform (DTMBWT) based feature extraction, and Linear Vector Quantization Classifier (LVQC) based MRI brain image classification. DTMBWT decomposes the MRI brain images in the frequency domain as the sub-bands for fuzzy-based low and high components to evaluate the features selected. The Sub-band Energy Features (SEF) for individual and sub-set ranking helps classify normal and abnormal images that LVQC for output prediction characterizes. The results show the classification accuracy of 95% using DTMBWT based SEF and LVQC classifiers.
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Main trends in development and law regulation of electronic health in the European Union
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The relevance of this research work lies in the fact that at present the EU policy standards are aimed at creating an ecosystem of digital (electronic) healthcare (eHealth). Digital medicine resources can radically transform healthcare, providing effective medical care, and improving diagnostics/treatment/rehabilitation methods. The aim of this article is to identify the main trends in the development and regulation of eHealth in the EU. Methods: A comprehensive review of trends and an analysis of key areas of digital health development in the EU based on the application of comparative law studies. The practical significance of the article is to identify some existing specific difficulties in the EU digital health infrastructure: those in their policy, those in accordance with regulatory requirements, in cybersecurity and exclusive rights to medical (personal) data, in the compatibility of national digital health platforms across Europe, in the principles of medical information handling, in digital therapy etc. Conclusions: Digital health in the EU is an area with an increased activity. In the EU, a common digital market is emerging, including digital health services within digital health, facilitated by the regulation and standardization of electronic prescriptions, patient data protection, digital identity and information security. The European digital health infrastructure, along with its achievements, is experiencing some difficulties, obsolete health regulations among them. At the same time, new approaches are now required to focus on digital tools and resources in order to provide full intelligent automation.
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Aims are to study the nature of the processes of carcinogenesis of experimental B16/F10 melanoma in uPA gene knockout mice modified by chronic neurogenic pain and investigate some electrophysiological mechanisms of melanoma development. Materials and methods. We used 48 C57BL/6-PlautmI. IBug-ThisPlau6FDhu/GFDhu mice of both genders with urokinase gene knockout and 102 C57BL/6 mice of both genders with the normal genotype. Chronic neurogenic pain (CNP) was produced due to bilateral ligation of the sciatic nerve. Against the above background, all animals were transplanted with B16/F10 melanoma. To study the mechanism of CNP, studies of the intracellular electrophysiological activity of neurons of the central nervous system of the snail Helix pomatia in the body in vivo were carried out. CNP was reproduced by dosed pressing of four main nerves with Fresnel hairs that with time turned into increasing pain. Membrane potential (MP), action potential (AP) and firing rate (FR) parameters of intracellular bio-potentials of the command neuron RPaG3, continuously recorded using an ultrathin glass microelectrode for 4-5 days, were analyzed. Results. It was detected that an activation of cancerogenesis during the modification of the progression of experimental B16/ F10 melanoma in C57BL/6-PlautmI.IBug-ThisPlau6FDhu/GFDhu mice with uPA gene knockout using CNP is accompanied by a 2-fold acceleration in the time of tumor production, stimulation of the growth of the primary tumor nodes from 1.05±0.08 cm3 to 9.50±0.98 cm3 (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Aim The aim of our studies was to discover responses of the membrane systems in neurons and cardiomyocytes as well as mechanisms of influences and effects produced by the broadband-spectrum stochastic electromagnetic radiation (BBSS EMR) on them according to data on membrane potential (MP) levels and action potential (AP) parameters obtained by us. Materials and methods Neurons from the isolated central neural system (CNS) of the snail Helix pomatia were selected to serve as a model for our experiments. We applied an electrophysiological technique implying recording of intracellular potentials of a neuron. The presented research work is of fundamental nature and reveals some intimate mechanisms of actions made by electromagnetic radiation (EMR) on the cytoplasm membrane of a neuron and its channels that is applicable to cardiomyocytes. An absolutely exclusive distinctive feature of our work is that the specific BBSS EMR used in our experiments has unique characteristics and offers broadband stochastic radiated frequencies in the range from 10n Hz to 10m Hz at an integral radiation power of only 0,1 µW...
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Subjects of our experimental studies were neurons in the snail Helix Pomatia, from which continuous intracellular recordings according to our specific microelectrode recording technique were produced. We have carried out original investigations of the processes of control and regulation of endogenous biological rhythms of neurons, observing them both under their background activity (free of stimulation) and under the action of the exogenous factors within a chronic experiment, which involved continuous recordings of activity from the neurons that covered periods from 50 to 60 hours, with an incubated ganglion cell life span up to four 24-hour days. In the neurophysiological experimental studies with recordings of intracellular activity of the identified CNS neurons in the Roman snail Helix Pomatia, we conducted a research into identification of a contribution of potential-dependent ion (K+, Ca2+, Na+) channels to formation of pacemaking oscillatory activity of the neurons and an interplay of the AP generation loci unequally or irregularly spaced. It has been shown that it is possible to activate at the same time 2-3 individual loci of generation of the Na+ spikes, differing in their amplitudes, which appear at different segments of the axo-dendritic axis of the neurons in the snail Helix Pomatia.
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The relevance of the research work lies in the fact that a significant number of surgical patients are at risk of intra or postoperative complications, or both, which is associated with prolonged stay in the hospital, costs and mortality. Reducing these risks is important for each individual patient, as well as for health care planners and managers. Insufficient tissue perfusion and cellular oxygenation due to hypovolemia, cardiac dysfunction, or both, are one of the primary causes of perioperative complications. Adequate perioperative management, guided by effective and timely hemodynamic monitoring, can contribute to a reduction of the risk of complications and thus potentially improve outcomes. This article discusses the technique of visualization of the cardiovascular system during the study of patients with perioperative myocardial injury. The purpose of this article is to identify ways to reduce the risk of complications using a specific technique for imaging the cardiovascular system during the study of patients with perioperative myocardial injury. The practical significance of the article implies that the results of the research can be used in the work of medical staff responsible for monitoring patients with myocardial injury in the perioperative period. To determine the most effective imaging technique for the cardiovascular system, an analysis of the existing imaging techniques, their advantages and disadvantages was used.
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Methodological basis of the relationship between art and medicine
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The aim of the article is to show the importance of methodological foundations in the relationship between art and medicine, whose source is the sacral core of the syncretic complex of primitive society, which includes the principles of harmony and beauty, the use of which makes it possible to have a therapeutic effect on human health under conditions where modern art of the West and East is characterized by the use of many new technologies that cancel the lines between abstract thinking and artistic activity. All this is directly related to the functioning of medicine III, which combines the methods of Eastern and technology and the instrument base of Western medicine, as well as new concepts and paradigms in the context of such trends of the modern world as aestheticization and technization.
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Methods and tools for three-dimensional cardiac modeling
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This article explores the use of methods and tools for three-dimensional modeling of the heart with computer-aided design systems. The use of three-dimensional modeling in medicine is a very pressing scientific and engineering problem. The object of study of this work is the process of three-dimensional cardiac modeling with CAD, and the subject of research is methods and means of three-dimensional modeling of the heart. This publication also provides the key elements required to create a 3D computational model of the heart for biophysical modeling. The article discusses some of the difficulties that arise at various stages of developing 3D cardiac modeling. The approaches which are currently available for three-dimensional computer modeling of the heart are briefly described herein.
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Mitochondrial therapy of melanoma B16/F10, pathophysiological parameters of tumor regression
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The aim is to evaluate the pathophysiological parameters of the efficacy of liver mitochondrial transplantation in animals with B16/F10 melanoma. Materials and methods. In our experiment we used female and male mice of BALB/c Nude strain (n=28). Experimental groups were as follows: the reference group (n=14) with B16/ F10 melanoma; the main group (n=14) with B16/F10 melanoma + mitochondrial therapy (MC therapy). Statistical analysis of results was carried out with the Statistica 10.0 software. Results. The subcutaneous tumor in the mice of both sexes became detectable on day 5 from the time of the tumor inoculation, and the regressive effect produced by MC therapy was recorded in the males beginning with day 8 of the tumor growth. At the end of the experiment, on day 22, the difference in the average volumes of the tumor node was reported to be 3.2 times, i.e. a significant inhibition of the tumor growth in the group of the males with MC therapy was revealed. In the females on day 5 of the tumor growth, differences in the volume of the tumor focus between the reference group and the group with MC therapy were not recorded, however, a statistically significant difference was found in the sex-related comparison of the groups of the animals with MC therapy. It was determined that in the females with MC therapy, the area of the tumor spot during that period (5 days) was 1.4 times (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Modern features of diagnosis and treatment of thoraco-abdominal injuries
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The improved algorithm of the diagnosing and treatment tactic of thoracoabdominal injuries can allows for timely diagnosis and the choice of adequate treatment tactics. The important role and opportunities of the endovideosurgical technologies are revealed in the diagnosis and surgical management of patients with thoracic and abdominal trauma. The results of diagnostics and treatment of patients with thoracoabdominal injuries using the diagnostic and treatment tactic algorithm improved by the authors were analyzed. The use of the offered diagnostic and treatment algorithm has improved the results of treatment of this severe category of patients. The clinical effectiveness of minimally invasive methods of the treatment and diagnosing of the thoracoabdominal injury is average 1.1 times higher than traditional surgical approaches
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Modern high-tech approaches to the diagnosis of gastrointestinal diseases
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The article discusses modern high-tech approaches to the diagnosis of gastrointestinal diseases. Revealing the relevance of the problem and the importance of accurate and timely diagnosis for the successful treatment of patients, the authors draw attention to the latest methods and technologies used in this field of medicine. The article discusses various diagnostic methods, including endoscopy, ultrasound, computed tomography, magnetic resonance imaging, molecular genetic analyses, as well as the use of artificial intelligence and machine learning to analyze medical data. The advantages and limitations of each method, their effectiveness and development prospects are discussed. The question is also raised about the need for an integrated approach to diagnosis, including a combination of various methods to improve the accuracy and reliability of the results. It is concluded that low-frequency imaging technologies provide a promising strategy for diagnosing diseases of the gastrointestinal tract. These technologies provide more complete information about the disease by integrating multiple contrast agents for imaging.
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Modern methods of diagnosis of gynecological diseases
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The article discusses modern methods of diagnosis of gynecological diseases. In recent years, there has been significant progress in the application of artificial intelligence (AI) in medicine, including gynecology. This paper presents an overview of modern methods of diagnosing gynecological diseases using AI. The authors consider various approaches, such as machine learning and deep learning, and describe their advantages in the context of improving diagnostic accuracy and speed. Special attention is paid to the analysis of large volumes of medical data, which allow us to create more effective diagnostic algorithms. Additionally, the potential of integrating AI into clinical practice and its impact on improving the quality of medical care for women is being considered, opening up new prospects in the field of gynecology.
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The article discusses modern strategies for the diagnosis and treatment of acute pancreatitis with an emphasis on the prospects of an interdisciplinary approach. Acute pancreatitis remains a serious disease with high mortality and a complex clinical course. In recent years, there has been a significant development of diagnostic and treatment methods, including the use of modern educational technologies, drug therapy, surgical techniques and interventional procedures. However, the problem of acute pancreatitis requires an integrated approach combining the efforts of various medical specialists - from therapists and gastroenterologists to surgeons and intensive care specialists. The authors discuss the latest diagnostic methods, such as computed tomography and endoscopic ultrasound diagnostics, as well as innovative treatment approaches, including minimally invasive surgical interventions, etc. Research based on interdisciplinary collaboration helps to reduce mortality from acute pancreatitis and improve the prognosis of patients. The development and implementation of integrated strategies for the diagnosis and treatment of acute pancreatitis using modern technologies are key areas in improving the effectiveness of medical care for patients with this disease.
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