Original research. Рубрика в журнале - Cardiometry
Level of delirium and its contributing factor among patients in ICU
Статья научная
Background: Delirium is an acute state of confusion characterized by a rapid onset, usually within hours to days, with changes in consciousness and cognitive changes. Delirium may also present as a form of agitation in intensive care patients. Delirium can affect up to 80% of patients in intensive care units and increase their length of stay and cost of hospitalization. Objectives: The main aim of the study is to evaluate the level of Delirium and its contributing factors among patients in intensive care unit. Methods: A descriptive study design was adopted for the study with 60 samples that met the inclusion criteria and were selected using convenience sampling technique. Data for demographic variables were collected using multiple-choice questionnaires, followed by assessment of delirium using the Confusion Assessment Method (CAM) scale. Results: 20%) had mild delirium, 13 samples (21.7%) of moderate delirium and 13 samples (21.7%) of severe delirium. Regarding the demographic variables of delirium, diabetes rapidly had a statistically significant association with the degree of delirium in ICU patients at p
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Leveraging learning interventions for talent development: an inductive approach
Статья научная
Purpose: The paper aims to focus on the question “How can we leverage learning interventions for talent development?” The rise in the need for learning and development for employees has become a priority and a primary reason for job dissatisfaction. Learning and development initiatives are believed to build the required through training campaigns, competencies, and exposure to critical experiences where employees across different bands and streams can be nudged to attend training, enhance their skills, and increase engagement. For an organization to have a learning culture, the most important thing is employee awareness concerning their learning and how their learning is benefiting the business and aligning the individual’s needs to organizational goals. It is usually found that because of time constraints and other factors, employees do not pay much attention to up skill themselves, which calls for a systematic framework to nudge them for inculcating a learning environment. Design/Methodology/Approach - An explorative, qualitative study based on focus groups designed. Findings: Due to time constraints and other factors, employees do not pay much attention to up skill themselves, which calls for a systematic framework to nudge them for inculcating the learning environment. Limitations: Based on the findings, few priority aspects may be crucial to the learning environment. Originality/Value: This paper serves the purpose of explaining the necessity of learning intervention techniques for talent development.
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Статья научная
Aims The observed experimental and natural phenomenon of cyclone-anticyclone vortex asymmetry implies that a relatively more stable and showing a longer life, as well as a relatively more intense mode of rotation with an anticyclonic circulation direction (opposite to the direction of rotation of the medium as a whole) is realized as compared with an oppositely directed rotation of the cyclonic vortex mode. Until now, however, it was not a success to identify a universal triggering mechanism responsible for the formation of the corresponding breaking of chiral vortex symmetry. Materials and methods In this paper we reveal the said linear universal instability mechanism of breaking of chiral symmetry in the sign of vortex circulation in the rotating medium in the presence of linear Eckman friction. Results Obtained is a condition for the linear dissipative - centrifugal instability (DCI), which leads (only when considering the external linear Eckman friction for an abovethreshold value of rotation frequency of the underlying boundary surface of fluid) to the breaking of chiral symmetry in the Lagrangian fluid particle dynamics and the corresponding realization of the cyclone-anticyclone vortex asymmetry...
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Lipstick color suggested using hybrid hidden Markov model
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In today’s lifestyle, facial makeup plays an important role in enhancing visual attractiveness a nd boosting one’s self-esteem. Makeup is known as the second skin of the women, and that too lipstick is a soul of the makeup. According to a survey, an average urban woman spends almost one year and three months of her life just wearing makeup. This much of the time is due to decision-making and choosing the best makeup style that would fit a particular age, skin complexion, profession, and occasion, requiring high imagination and full art. Many makeup recommendations systems exist, but no solitary system has existed to recommend a lipstick color properly to solve this problem computationally. Therefore, as a tiny step towards helping women save their time in decision-making, the proposed model puts forward an idea of a hybrid recommendation model for lipsticks alone. This proposed methodology uses a hidden Markov model to unleash the possible color of the lipsticks based on the given attributes. The collaborative filtering system catalyzes the process to recommend the best lipstick colors using a hybrid recommendation model.
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Статья научная
Introduction: Hypertension is found to be the prime cause of death worldwide in spite of a number of available treatments which suggests that there is a need of discovering new lead molecules that would be more effective to treat cardiovascular disease (CVD). Liriodendrin, the lignan phytoconstituent possesses potential pharmacological effects. Literature survey suggests that liriodendrin could be effective in mitigating hypertension considering its structural similarity with reported cardiovascular protective drugs. Hence liriodendrin is investigated to reveal its mechanism of actions to support its antihypertensive property. Methods: Hypertension was induced in male wistar rats with DOCA salt. Hypertensive rats were treated with liriodendrin for 4 weeks. Blood pressure, heart rate, body weight, lipid profile, serum nitrite levels, vascular reactivity to various catecholamines, in-vitro calcium channel blocking assays, antioxidant assay, determination of aortic calcium level, endothelial function, expression of eNOS analysis were studied. Result: Liriodendrin was found safe orally up to 2000 mg/kg. It showed a significant decrease in heart rate, blood pressure and mean arterial pressure. In-vitro study on the isolated rat aorta revealed the calcium channel blocking potential of liriodendrin. Vascular reactivity to various catecholamines was normalized. Vascular endothelium was significantly protected by the enhanced release of nitric oxide and eNOS expression by the western blot technique. Oxidative stress was also significantly reduced. Conclusion: Liriodendrin was found to be beneficial in hypertension as it produced vasorelaxation by blocking calcium channels, enhancing nitric oxide release, and reducing oxidative stress. Thus, liriodendrin may be useful to relieve hypertension and cardiovascular complications.
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MRI brain image classification using linear vector quantization classifier
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The metastases cancer other than the lifestyle-related or environmental related no known facts for the brain tumors. Only factors that may cause brain tumors might be the exposure to high ionizing radiation and a family history of any brain disease also increase brain cancer risk. The cancerous brain is a brain disorder that shapes masses in cells called tumors. The early diagnosis of brain cancer using the Magnetic Resonance Imaging (MRI) scan image for cancer disease is required to reduce the mortality rate. Dual-Tree Mband Wavelet Transform (DTMBWT) based feature extraction, and Linear Vector Quantization Classifier (LVQC) based MRI brain image classification. DTMBWT decomposes the MRI brain images in the frequency domain as the sub-bands for fuzzy-based low and high components to evaluate the features selected. The Sub-band Energy Features (SEF) for individual and sub-set ranking helps classify normal and abnormal images that LVQC for output prediction characterizes. The results show the classification accuracy of 95% using DTMBWT based SEF and LVQC classifiers.
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Main trends in development and law regulation of electronic health in the European Union
Статья научная
The relevance of this research work lies in the fact that at present the EU policy standards are aimed at creating an ecosystem of digital (electronic) healthcare (eHealth). Digital medicine resources can radically transform healthcare, providing effective medical care, and improving diagnostics/treatment/rehabilitation methods. The aim of this article is to identify the main trends in the development and regulation of eHealth in the EU. Methods: A comprehensive review of trends and an analysis of key areas of digital health development in the EU based on the application of comparative law studies. The practical significance of the article is to identify some existing specific difficulties in the EU digital health infrastructure: those in their policy, those in accordance with regulatory requirements, in cybersecurity and exclusive rights to medical (personal) data, in the compatibility of national digital health platforms across Europe, in the principles of medical information handling, in digital therapy etc. Conclusions: Digital health in the EU is an area with an increased activity. In the EU, a common digital market is emerging, including digital health services within digital health, facilitated by the regulation and standardization of electronic prescriptions, patient data protection, digital identity and information security. The European digital health infrastructure, along with its achievements, is experiencing some difficulties, obsolete health regulations among them. At the same time, new approaches are now required to focus on digital tools and resources in order to provide full intelligent automation.
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Статья научная
Aims are to study the nature of the processes of carcinogenesis of experimental B16/F10 melanoma in uPA gene knockout mice modified by chronic neurogenic pain and investigate some electrophysiological mechanisms of melanoma development. Materials and methods. We used 48 C57BL/6-PlautmI. IBug-ThisPlau6FDhu/GFDhu mice of both genders with urokinase gene knockout and 102 C57BL/6 mice of both genders with the normal genotype. Chronic neurogenic pain (CNP) was produced due to bilateral ligation of the sciatic nerve. Against the above background, all animals were transplanted with B16/F10 melanoma. To study the mechanism of CNP, studies of the intracellular electrophysiological activity of neurons of the central nervous system of the snail Helix pomatia in the body in vivo were carried out. CNP was reproduced by dosed pressing of four main nerves with Fresnel hairs that with time turned into increasing pain. Membrane potential (MP), action potential (AP) and firing rate (FR) parameters of intracellular bio-potentials of the command neuron RPaG3, continuously recorded using an ultrathin glass microelectrode for 4-5 days, were analyzed. Results. It was detected that an activation of cancerogenesis during the modification of the progression of experimental B16/ F10 melanoma in C57BL/6-PlautmI.IBug-ThisPlau6FDhu/GFDhu mice with uPA gene knockout using CNP is accompanied by a 2-fold acceleration in the time of tumor production, stimulation of the growth of the primary tumor nodes from 1.05±0.08 cm3 to 9.50±0.98 cm3 (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Статья научная
Aim The aim of our studies was to discover responses of the membrane systems in neurons and cardiomyocytes as well as mechanisms of influences and effects produced by the broadband-spectrum stochastic electromagnetic radiation (BBSS EMR) on them according to data on membrane potential (MP) levels and action potential (AP) parameters obtained by us. Materials and methods Neurons from the isolated central neural system (CNS) of the snail Helix pomatia were selected to serve as a model for our experiments. We applied an electrophysiological technique implying recording of intracellular potentials of a neuron. The presented research work is of fundamental nature and reveals some intimate mechanisms of actions made by electromagnetic radiation (EMR) on the cytoplasm membrane of a neuron and its channels that is applicable to cardiomyocytes. An absolutely exclusive distinctive feature of our work is that the specific BBSS EMR used in our experiments has unique characteristics and offers broadband stochastic radiated frequencies in the range from 10n Hz to 10m Hz at an integral radiation power of only 0,1 µW...
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Статья научная
Subjects of our experimental studies were neurons in the snail Helix Pomatia, from which continuous intracellular recordings according to our specific microelectrode recording technique were produced. We have carried out original investigations of the processes of control and regulation of endogenous biological rhythms of neurons, observing them both under their background activity (free of stimulation) and under the action of the exogenous factors within a chronic experiment, which involved continuous recordings of activity from the neurons that covered periods from 50 to 60 hours, with an incubated ganglion cell life span up to four 24-hour days. In the neurophysiological experimental studies with recordings of intracellular activity of the identified CNS neurons in the Roman snail Helix Pomatia, we conducted a research into identification of a contribution of potential-dependent ion (K+, Ca2+, Na+) channels to formation of pacemaking oscillatory activity of the neurons and an interplay of the AP generation loci unequally or irregularly spaced. It has been shown that it is possible to activate at the same time 2-3 individual loci of generation of the Na+ spikes, differing in their amplitudes, which appear at different segments of the axo-dendritic axis of the neurons in the snail Helix Pomatia.
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Статья научная
The relevance of the research work lies in the fact that a significant number of surgical patients are at risk of intra or postoperative complications, or both, which is associated with prolonged stay in the hospital, costs and mortality. Reducing these risks is important for each individual patient, as well as for health care planners and managers. Insufficient tissue perfusion and cellular oxygenation due to hypovolemia, cardiac dysfunction, or both, are one of the primary causes of perioperative complications. Adequate perioperative management, guided by effective and timely hemodynamic monitoring, can contribute to a reduction of the risk of complications and thus potentially improve outcomes. This article discusses the technique of visualization of the cardiovascular system during the study of patients with perioperative myocardial injury. The purpose of this article is to identify ways to reduce the risk of complications using a specific technique for imaging the cardiovascular system during the study of patients with perioperative myocardial injury. The practical significance of the article implies that the results of the research can be used in the work of medical staff responsible for monitoring patients with myocardial injury in the perioperative period. To determine the most effective imaging technique for the cardiovascular system, an analysis of the existing imaging techniques, their advantages and disadvantages was used.
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Methodological basis of the relationship between art and medicine
Статья научная
The aim of the article is to show the importance of methodological foundations in the relationship between art and medicine, whose source is the sacral core of the syncretic complex of primitive society, which includes the principles of harmony and beauty, the use of which makes it possible to have a therapeutic effect on human health under conditions where modern art of the West and East is characterized by the use of many new technologies that cancel the lines between abstract thinking and artistic activity. All this is directly related to the functioning of medicine III, which combines the methods of Eastern and technology and the instrument base of Western medicine, as well as new concepts and paradigms in the context of such trends of the modern world as aestheticization and technization.
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Mitochondrial therapy of melanoma B16/F10, pathophysiological parameters of tumor regression
Статья научная
The aim is to evaluate the pathophysiological parameters of the efficacy of liver mitochondrial transplantation in animals with B16/F10 melanoma. Materials and methods. In our experiment we used female and male mice of BALB/c Nude strain (n=28). Experimental groups were as follows: the reference group (n=14) with B16/ F10 melanoma; the main group (n=14) with B16/F10 melanoma + mitochondrial therapy (MC therapy). Statistical analysis of results was carried out with the Statistica 10.0 software. Results. The subcutaneous tumor in the mice of both sexes became detectable on day 5 from the time of the tumor inoculation, and the regressive effect produced by MC therapy was recorded in the males beginning with day 8 of the tumor growth. At the end of the experiment, on day 22, the difference in the average volumes of the tumor node was reported to be 3.2 times, i.e. a significant inhibition of the tumor growth in the group of the males with MC therapy was revealed. In the females on day 5 of the tumor growth, differences in the volume of the tumor focus between the reference group and the group with MC therapy were not recorded, however, a statistically significant difference was found in the sex-related comparison of the groups of the animals with MC therapy. It was determined that in the females with MC therapy, the area of the tumor spot during that period (5 days) was 1.4 times (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Modern features of diagnosis and treatment of thoraco-abdominal injuries
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The improved algorithm of the diagnosing and treatment tactic of thoracoabdominal injuries can allows for timely diagnosis and the choice of adequate treatment tactics. The important role and opportunities of the endovideosurgical technologies are revealed in the diagnosis and surgical management of patients with thoracic and abdominal trauma. The results of diagnostics and treatment of patients with thoracoabdominal injuries using the diagnostic and treatment tactic algorithm improved by the authors were analyzed. The use of the offered diagnostic and treatment algorithm has improved the results of treatment of this severe category of patients. The clinical effectiveness of minimally invasive methods of the treatment and diagnosing of the thoracoabdominal injury is average 1.1 times higher than traditional surgical approaches
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Статья научная
To study the effect of comorbid pathology: obesity of degree 2-3 on the level of sex steroid hormones and their receptors in the tumor and its surrounding tissue in patients with endometrial cancer (EC). Materials and methods. In 30 patients with endometrioid adenocarcinoma T1-3N0-1M0 (the main group, 15 females with obesity grade 2-3 (BMI≥35); the reference group 15 females with normal BMI) in samples of the tumor and its perifocal zone taken after surgical treatment, the levels of estradiol (E2), estrone (E1), testosterone (T), progesterone (P4), androgen receptors (AR), progesterone receptors (RP4), estrogen receptors (ERα and ERβ) were determined by ELISA method. Statistical analysis was performed with STATISTICA 10.0. Results. Obese EC patients showed longer healing of postoperative wounds, slow recovery, and more frequent tumor metastasizing to regional lymph nodes. In the tumor samples in all patients, compared with the intact endometrium, the levels of estrogens, testosterone and their receptors were higher. Obesity accompanying the malignant process led to a local increase in the levels of estrogens, testosterone, progesterone and AR, ERα and ERβ in the tumor. In the tumor samples, there were no significant differences from the presence of obesity in the levels of RP4. In the perifocal zone of the tumor in patients with comorbid pathology, compared with the parameters in the reference group, the level of E2, P4 and T was also higher, but the content of all steroid receptors was lower. Conclusion. Obesity aggravates hyperestrogenism and progesterone deficiency in adenocarcinoma and increases its enrichment with the androgen and estrogen receptors with the prevalence of ERα over ERβ that may cause the autocrine-paracrine regulation of the growth and metastasizing of the malignant process in patients with endometrial cancer.
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Pseudomonas aeruginosa is rod-shaped with Gram-negative pathogens. It causes disease in humans and animals. P. aeruginosa interferes with the burn cure rates and can lead to increased death among the patients. The current study aims to detect pseudomonas aeruginosa isolates using the classical biochemical methods and polymerase chain reaction technique after isolating pseudomonas aeruginosa from burns cases in Baghdad-Iraq. A sterile swab takes Fifty samples randomly from Al-Yarmouk Teaching Hospital and Kadhemia Hospital. All samples were inoculated on rich media and then submitted to staining by gram stain and the biochemical tests (lactose fermenter, oxidase, and catalase….). The positive samples for biochemical tests are submitted to the PCR test for confirmation diagnosis. All the data related to age and gender are recorded to determine the epidemiological aspects. The findings demonstrate that the percentage of p. aeruginosa in burn cases using biochemical testing was 17/50 (34%), and the percentage of p. aeruginosa isolates from burn samples using the PCR technique was 13/17 (76.4%). In addition, the percentage of P. aeruginosa isolates using PCR in the males was 8/13 (61.5%), while the percentage of p. aeruginosa isolates using PCR in the females was 5/13 (38.4%). The infection percentage in the age groups (1-10), (11-20), (21-30), (31-40), and (41-50) years were (7.6%), (7.6%), (7.6%), (30.7%), and (46.1%), respectively. The conclusion is that PCR is an accurate method for detecting Pseudomonas aeruginosa. Pseudomonas aeruginosa infection is occurring higher in burn males than in burn females. Pseudomonas aeruginosa infection occurs more in the elderly than in young children.
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Статья научная
Aims The aim of the present paper is to study the morphofunctional changes in the tumor tissue and peripheral zone in experimental animals under the influence of extremely high-frequency electromagnetic radiation (EHF EMR). Combined effect of EHF EMR and ultra-low-frequency magnetic field (ULF MF) without the use of special anti-tumor agents is to be studied as well. Materials and methods The experiments have been performed on 56 outbred male rats with inoculated sarcoma 45. Low intensity EHF EMR and ULF MF exposures have been carried out only on animals’ heads. Histological and morphometric study of the sarcoma 45 tumor tissue and its peripheral area has been performed. Results In case of the combined electromagnetic exposure (in 65 % of cases) against the background of the sTable anti-stressor adaptation reactions an evident anti-tumor effect has been observed. Under effective combined electromagnetic action, lymphocyte infiltration of the tumor tissue and its peripheral zone was enhanced not only in comparison with the reference group, but also compared to the EHF EMR monoexposure. Conclusions Thus, significant enhancement of the tumor tissue infiltration by leukocyte cells under the combined effect of EHF EMR and ULF MF may indicate mobilization of the local immune mechanisms due to the activation of the neuroendocrine and immune system organs.
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Morphological and anatomical study of the new plant collection phytofrufol
Статья научная
For the first time, the morphological and anatomical features of the herbal preparation "Phytofrufol", developed on the basis of medicinal plants growing in the conditions of Uzbekistan, were studied. The results obtained will allow identification of the studied collection, provide the possibility of developing regulatory documents and introducing this herbal collection into medical practice as a new diuretic drug.
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Morphometry of the internal structures of the graylag goose (Anser anser) heart
Статья научная
As a result of our research, it was found that the heart of the graylag goose Anser anser is a hollow muscular organ weighing 28.950±0.08 g in females (relative 0.73%), 29.091±0.09 (0.69%) in males, with a length: ♀ 51.55±0.07 mm, ♂ 52.66±0.08; it is oval, slightly elongated. Auricular appendices are oval, slightly elongated, in size: the right one with a length ♀14.98±0.05 mm, ♂ 15.57±0.06; with a width ♀ 21.99±0.0 mm, ♂ 22.23±0.05; their wall thickness data are as follows: ♀ 0.47±0.05 mm, ♂ 0.49±0.06; left - ♀ 12.27±0.05 mm, ♂ 12.98±0.06; ♀ 14.89±0.07 mm, ♂ 15.04±0.08; ♀ 0.71±0.03, ♂ 0.78±0.02 mm, respectively; the convex base. The pectineus muscles are located in the walls of the auricular appendices. From the interatrial crest, four to eight pectineal muscles extend, which are connected by smaller muscles, thereby forming a finely looped network. The left ventricle is ♀ 40.97±0.09 mm long, ♂ 41.05±0.08; with a width ♀ 14.89±0.09, ♂ 14.98±0.09; wall thickness ♀ 8.29±0.05, ♂ 8.35±0.07. It contains a tricuspid valve, which has three cusps: septal, caudal, lateral. The right ventricle is ♀ 31.39±0.05 mm long, ♂ 31.49±0.05; with a width ♀ 6.29±0.03, ♂ 6.39±0.05; wall thickness ♀ 2.89±0.03, ♂ 2.91±0.04, has a crescent-shaped atrioventricular opening. The valve length is ♀ 19.17±0.04 mm, ♂ 21.17±0.05 mm.
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Статья научная
The object of the study is the hearts of four young reproductive females of the Amur leopard cat, a rare mammal representative of the cat family. The animal is untamed and lives only in the wild. The material was selected during the autopsy according to generally accepted methods. The age of the studied individuals of the Amur leopard cat was determined taking into account the data; the internal structure features of the heart were studied. Earlier, we described the morphometric parameters of different age groups male hearts. The heart of the studied individuals is slender, ellipsoid in shape; the myoendocardial formations of the atria have a well-defined ridge-like structure. The walls of the ventricles are characterized by pronounced trabeculation. The papillary and trabecular complex includes: trabeculae carneae of varying intensity, depending on the localization on the wall; septomarginal trabeculae that have their own distinctive features in the right and left ventricles; main and additional papillary muscles. The septomarginal trabeculae of the right ventricle have a pronounced muscular structure; the corresponding formations of the left ventricle are thin, tendon-like, significantly exceeding the first in length. The most pronounced papillary muscles are localized in the left ventricle. Papillary muscles of the right ventricle are expressed slightly, with the exception of the parietal muscles
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