Original research. Рубрика в журнале - Cardiometry
Статья научная
Aims The article presents the results of an experimental study of the cardiometric detection of a person's emotional reactions to verbal, audial and visual stimuli. Materials and methods To test the hypothesis of our study, we carried out a series of experiments in which two groups of stimuli have been used purposefully, one of which had to cause sthenic and the other asthenic reactions in our examinees. In order to activate various types of sensory systems, only stimuli of the audial modality (the A-type stimuli), only visual modality (the V-type stimuli), and also stimuli with a combination of audiovisual modalities (the VА -type stimuli) have been included in each group. In addition, as stimuli, we prepared a list of imaginary situations (the I-type stimuli) to initiate either sthenic or asthenic emotional reactions in the examinees. For the cardiological data recording and subsequent assessment of HRV, we used the Cardiocode PC-assisted hemodynamic analyzer. Portable eyetracker GP-3 has been employed to record the examinees' oculomotor reactions to visual stimuli...
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The paper presents our experimental evidence of validity of our hypothesis that definite, substantively different, psychophysiological states of a human individual can be really fixed with the use of metaphoric associative cards, and that transitions from one psychophysiological state to another are accompanied by significant changes in the performance of the human organism, and, first of all, in the performance of the heart. It has been shown that the metaphoric associative cards can serve not only as a good forecasting tool, a sort of predictors of human behavior in certain emotionally charged, stress-provoking, situations, but also as a means for active modeling of optimal mode to adequately overcome these difficulties.
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Cardiometric fingerprints of various human ego states
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The article presents experimental evidence of the validity of the hypothesis that theoretical construct “ego state”, in addition to the psychological content, actually reflects the physiological mobilization of a human individual to provide a certain type of response. It is shown that the mobilization is manifested in a certain specific pattern inherent to the cardiovascular system performance. Experimental evidence is given herein that the ego-state theoretical construct really captures reasonably definite, content-related different psycho-physiological states of an individual. It is shown that the transitions from one ego state to another are indeed accompanied by significant changes in heart rate variability, which has been estimated using the Baevsky stress index (SI). The article also provides experimental data confirming the validity of using the Baevsky stress index (SI) to assess the effectiveness of the application of the transactional analysis as a psychotherapeutic and psychocorrectional technique.
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Cardiometric taxonomy of stress-inducing potential in diverse domestic situations
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Aims The aim of our study is to empirically verify the conceptual possibility of constructing a taxonomy of diverse domestic situations, which may become the basis for choosing the best ways to increase an individual stress resistance in a human subject. Materials and methods To achieve the aim, after ranking of the subjective evaluations of the occurrence rate of this sort of situations and the degree of intensity of stress induced by the situational cases, we have prepared a set of their laconic descriptions. As a result, a catalogue of 10 paired tasks has been prepared by us. One of these tasks offers that an examinee should imagine and hold in his/her memory for a certain time an image of a stress-inducing situation case as designated by the examiner. The other examinee in this pair has been instructed to imagine an alternative situation, when anticipated are a high level of the calm, trouble-free state, physical comfort and good emotional balance. During the execution of each task, an ECG and a rheogram of every examinee have been recorded...
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The paper investigates the features of an interdisciplinary approach in the field of treatment and supportive therapy of pediatric patients with oncological diagnoses having concomitant problems in the field of cardiology. The authors note that the formation of an interdisciplinary approach in the field of prevention and treatment of cardiopathologies in children with cancer will eliminate gaps in the knowledge of specialists and improve the results of treatment of children with cancer. Early detection of cardiovascular diseases and preventive initiation of drug treatment improves the quality of life as well as increases the long-term survival rates of such children.
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This article presents some results of processing of phonocardiography signals (PCG signals) for cardiac cycle tone identification under ambient noise of varying intensity. For PCG signal processing, proposed is a refined approach based on active band pass filter bank, which allows improving an accuracy of cardiac cycle tone identification under ambient noise. The efficiency of the application of the proposed approach has been demonstrated by the respective qualitative, quantitative results and experimental data obtained upon processing of PCG signals according the offered technique. A 3D model of the cardiac cycle tone identification system has been developed based on this conceptual idea.
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The hypothalamic-pituitary-adrenal axis (HPA) makes the body’s response to various stress factors, interacting with the thyroid and gonadal axis. The aim of our work was to study the effect by induced hypothyroidism on changes in the functioning of the HPA axis in rats with Guerin’s carcinoma of both sexes. Materials and methods. The experiment was performed in white outbred rats of both sexes. Hypothyroidism was induced in animals by medication for 30 days with Mercazolil, and then Guerin’s carcinoma was transplanted (the main group). The reference groups covered animals with the independent growth of Guerin’s carcinoma and with independent hypothyroidism, as well as intact animals (the normal conditions). On day 18 of the tumor growth, the animals were sacrificed, and, using standard ELISA kits, in the serum and the homogenates of the adrenal glands, the tumor and the perifocal zone, the level of cortisol was determined; in the homogenates of the hypothalamus we measured the concentration of CT-releasing hormone (CRH) and in the pituitary gland the concentration of ACTH. Results. Induced hypothyroidism both in males and females caused adrenal insufficiency. The growth of Guerin’s carcinoma increased the level of CT-releasing hormone in males by 9.6 times and cortisol in the adrenal glands in females and males by 1.3 times and 2.3 times (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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The article presents the results of the study of the nutritional, biological value and the chemical composition of the Nile tilapia fish, grown in the natural hot spring of Chondzhy, using different formulations of grower feed. Also, the chemical composition and nutritional value of the sharptooth catfish were investigated for comparative analysis. Nutritional value was characterized by the content of water, nitrogenous matter, lipids, minerals, carbohydrates and vitamins. It was found that this feed additive is completely harmless, does not have negative consequences.
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Chronic gastritis in pediatrics
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Chronic gastritis is one of the most common diseases of the gastrointestinal tract. High rates of gastritis in children are associated with poor nutrition, physical inactivity, drug abuse, bad habits, a number of concomitant diseases, immune disorders, allergization of the body, and stress. Although a significant proportion in the structure of chronic gastritis is occupied by gastritis associated with Helicobacter pylori infection, many clinical forms are diagnosed that are not associated with the presence of a microbial pathogen in the gastric mucosa. The goal is to highlight the problem of chronic gastritis in children, including risk factors, etiology, clinical manifestations, diagnosis and treatment.
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Our aim is to study special features of actions and effects of chronic neurogenic pain on concentrations of biogenic amines in the brain in tumor-bearing urokinase knockout mice (uPA). Materials and methods Our research work has been conducted in female/male mice line C57BL/6 (uPA+/+) n=48 and line C57BL/6-Plautm1.1Bug-ThisPlauGFDhu/GFDhu (uPA) -/-) n = 48 with targeted mutation of protein incapable of binding to receptor of the urokinase-type plasminogen activator, i.e. in the urokinase knockout (uPA) mice. The animals of each line have been divided into subgroups (n= 6) as follows: the intact animals, the chronic neurogenic pain mice (CNP), the mice with the growth of inoculated melanoma (B16/F10) and the mice with combination melanoma growth plus chronic neurogenic pain (B16/F10 + CNP). In 10% of the brain homogenates, with the use of standard analysis system method ELISA (Cusabio. China), we have determined concentrations of adrenaline (A), noradrenaline (NA), dopamine (DA), histamine, serotonin (5HT) and 5-hydroxyindoleacetic acid (5-HIAA). Obtained statistic data have been processed using the Statistica 10.0 package. Results The concentration of biogenic amines in the brain in the intact uPA-/- mice has been found to be higher than in the intact uPA+/+ animals, and the response to the growth of inoculatedmelanoma B16/F10 and CNP under single-factor action and combined-action variants depends both on the sex and the condition of the urokinase gene. In the uPA-/- female/male mice in response to the only CNP and the only B16/F10 growth the serotonergic system in the brain has been activated. In contrast thereto, in case of the melanoma growth against the CNP background, we have revealed a decrease in the level of 5HT, DA in the female/male mice and NA in the female animals. Conclusion One of the factors resulting in cancellation of the genetically determined inhibition of the growth of inoculated melanoma B16/F10 under its combination with developing CNP in the uPA-/- mice is suppression of their noradrenergic, serotonergic and dopaminergic systems, initially activated in the intact uPA-/- animals to compensate their urokinase deficit.
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The article is devoted to the most pressing issues of studying the clinical and epidemiological features concerning the detection and course of tuberculosis infection in patients with concomitant pathologies. Such pathologies include cancer, diseases of the endocrine system, of the respiratory system (chronic bronchitis, pneumoconiosis), gastric ulcer, pathology of the urinary system, exhaustion due to insufficient nutrition, smoking. Using genetically engineered biological drugs (GEBPs) in practice reduces the activity of inflammatory phenomena due to suppression of the immune response, but increases the risk of developing infectious diseases, primarily tuberculosis. Immunosuppressive therapy in organ transplant patients is also associated with the risk of developing tuberculosis. A special nature of immune disorders develops during HIV infection, a comorbid disease in patients with tuberculosis. The diseases listed above create a medical risk group in patients with immunocompromise, which is the basis for the development of tuberculosis. In addition to the risk of developing infection, patients with concomitant diseases have unfavorable results from treatment tuberculosis, which does not allow achieving abacillation in a short time, thereby maintaining a reservoir of infection in society. In this regard, the purpose of our research was to study the clinical and epidemiological features of the detection and course of tuberculosis infection in patients with concomitant pathology A study was conducted using a continuous sampling method for the period from December 2020 to August 2021. 67 medical records of an inpatient at the state budgetary healthcare institution “Republican Clinical Anti-TB Dispensary” (Ufa) were analyzed. The groups were formed based on the detection of concomitant pathology (main, n=33) and its absence (control, n=34). To achieve the goal of the study, a comparative analysis of methods for detecting tuberculosis and clinical manifestations of tuberculosis was performed; prevalence of the process, detection of the fact of bacterial excretion and drug sensitivity from December 2020 to August 2021. 67 case histories of Mycobacterium tuberculosis (MBT) in patients of the studied groups were analyzed. Statistical data processing was performed using licensed software Statistica 6.0 when calculating two types of data: discrete and interval. To assess the chances of detecting the studied factor in both groups, the indicator (OR) was used to calculate the 95% confidence interval (CI). Interval indicators were studied by t-test for independent samples, with Livigne’s correction
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Camel milk is a natural product that has dietic and medicinal properties. Camel milk is widely used in the field of non-conventional medicine. It is scientifically proven that camel milk has the ability to help in the medical treatment of cancer and leukemia, due to the presence of substances that eliminate out of the body the compounds that provoke the development of cancer. In addition, such milk is used during the treatment of tuberculosis, ulcers and some other problems with the gastrointestinal tract. This product is recommended to use for problems with the pancreas, liver and intestines, as well as diabetes mellitus. The goal of research was to study the clinical parameters of patients with type 2 diabetes mellitus. The study group consisted of 15 patients with medium severity. The patients took freeze-dried shubat (camel milk) for 60 days. As a result of the treatment, an improvement in clinical symptomatology and laboratory parameters was achieved in all patients with diabetes mellitus. The results of the study showed the therapeutic and dietary potential of camel milk, due to its unique quality composition.
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Cochlear models used in cochlear implant research
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Over the past few decades, cochlear implants have undergone significant changes due to intensive research through experimental and computational analysis. However, obtaining an accurate and reliable cochlear model remains an open issue. Invasive measurements on the human ear are hardly possible, and the only alternative is animal models, but even this is not an ideal option, as animal cochleae are anatomically significantly different from the human cochleae. In this context, an ear model based on the latest knowledge of the physiology and molecular principles of hearing will allow the study of hearing disorders, whether they are caused by some genetic or external factors. It will also enable the experts to learn more about the detailed mechanisms of various forms of hearing impairment and open up avenues for the improvement of cochlear implants. With this in mind, the aim of this article is to explore different approaches to creating models of the human cochlea used in cochlear implant research. In the process of the study an individual emphasis is made on the variability of the human cochlea, sizes of its separate elements and shapes. Also considered are herein such methods of cochlea model creation as 3D-modeling, computer graphics and finite element method, as well as computational approaches. The results obtained allow us to state the fact that there are no ideal approaches and techniques to date available. The limitations of the models are related to difficulties in reproducing the microenvironment of the human cochlear apparatus, the need for clear validation and accurate parameterization of the main parameters of the cochlea. At the same time, we can expect that with a rapid increase in the available computational resources and development of effective computational methods, the models of the cochlea and cochlear implant will become more accurate and allow analyzing the cochlear micromechanics and the temporal response of the tissue to external stimulation.
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Cognitive and ethical reasons for the dissident movement in epidemiology
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The article discusses several fundamental reasons for the emergence of such a significant phenomenon as the anti-vaccination movement. An attempt is made to classify the causes thereof. The theory of the phases of the vaccination cycle by Robert Chen is presented herein. A concept of cognitive simplicity and design of illusory patterns to strengthen psychological control over a stressful situation was developed by the Moscow anthropologist Alexandra Arkhipova. The decision to refuse vaccination is often accompanied by an inability to properly rank associated risks and distrust of science. The level of distrust by citizens in the government and healthcare system activity, and, conversely, excessive trust in some populist personalities, is also an important reason for the dissent in epidemiology. This article provides numerous examples from the history of smallpox, cholera and coronavirus epidemics. In conclusion, the article considers the problem of the trust and mutual responsibility in a society.
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Coincidence of renal artery stenosis and coronary artery stenosis
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Aims The aim of this study was to investigate the prevalence of renal artery stenosis in patients with severe coronary artery disease or stenosis of the left main coronary artery. Materials and methods This cross-sectional study was performed on 264 patients with a history of severe hypertension who were candidates for coronary artery angiography in Yazd Afshar Hospital. During coronary angiography, renal angiography was performed on all of the patients. At the same time, we investigated the renal artery stenosis and its association with a history of diabetes mellitus, high body mass index (BMI), hyperlipidemia, and other cardiovascular risk factors. Renal artery stenosis was defined based on luminal narrowing: mild (50%), moderate (75%), and severe (75%) decrease in luminal diameter. Collected data were analyzed by SPSS software (version 18.0). Results Among 264 patients, 54.92% were males and 45.08 % were females with the average age of 58.0±8.6. 83.71% of the patients had coronary artery disease and included 52.94% hyperglycemic, 63.39% diabetic, and 29.86% smokers...
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This paper presents some results of a comparative analysis of characteristics of electrodes to estimate the accuracy of recording long-term ECG signal parameters. To obtain the characteristics of the analyzed electrodes of various types, the resistance values of the contact conductive substance of each of them were measured. The relationship of the measured characteristics of the electrodes is analyzed, and the accuracy of recording ECG signal parameters, using the basics of statistical decisions, is estimated. The analysis results show that the harder the contact conductive substance of the electrodes, the more accurately recorded ECG signal parameters.
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Background: Skull base ENT (Ear, Nose, and Throat) pathologies present a diagnostic challenge due to their intricate location. Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scans are commonly used diagnostic tools for detecting these pathologies. This study aims to associate the diagnostic exactness of MRI and CT scans in detecting skull base ENT pathologies.
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BACKGROUND: All patients with T1DM are on life-long insulin injection . However, since last decades with evolving diabetes technology ,there is a paucity of research on glycemic and self satisfaction effectiveness of new insulin pump and CGM devices in Saudi Arabia population whom they have different lifestyle and race. PATIENTS AND METHODS: A cross-sectional study was con-ducted at King Abdulaziz Medical City Endocrine Center in Ri-yadh, Saudi Arabia. The study focused on a sample of patients with type 1 diabetes aged 14 years and above using either a sensor-augmented insulin pump (Medtronic MiniMed 640G, 740G), insulin pump without a sensor (Medtronic Paradigm VEO 754), or multiple daily insulin injections for at least 6 months.
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Background: Coronary artery disease (CAD) is a leading cause of death worldwide. Intravascular imaging is an important tool in the arsenal of each interventional cardiologist. While angiography provides a two-dimensional image of a three-dimensional structure, intravascular imaging enhances understanding by providing detailed cross-sectional images. This study aimed to investigate the discrepancies in coronary vessel sizing between quantitative coronary angiography (QCA) and intravascular ultrasound. Methods: This cohort study was conducted on 69 patients who were referred for elective coronary angiography. Patients were subjected to history taking, examination, blood samples, electrocardiogram (E.C.G.), and echocardiography. Then, a comparison of each vessel’s luminal diameter by QCA and IVUS was done. Results: The study included 69 patients; The mean age was 54.7 ± 9.7. There was a statistically significant difference between the studied vessels regarding the discrepancy between luminal diameters measured by IVUS and QCA. IVUS luminal diameter was larger than QCA luminal diameter (the median difference in measures of QCA and IVUS in the left main artery, LAD, LCX, and RCA were -0.8, -0.55, -0.4, and -0.5 respectively). Furthermore, there is a statistically significant difference between the studied vessels regarding the presence of a difference >0.75 mm between the luminal diameters measured by IVUS and QCA (Difference >0.75 mm in the left main artery, LAD, left circumflex and RCA were 55.8%, 21.7%, 30.8%, and 15.4% respectively). Conclusion: Coronary lesions were underestimated by QCA in comparison to IVUS regarding luminal diameter, especially the left main (LM).
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ated single-photon emission computed tomography (SPECT) allows for the assessment of myocardial left ventricular ejection fraction and left ventricular volumes. There is conflicting data regarding the difference between automated and manual processing of gated myocardial SPECT images. The purpose of this retrospective “cross-sectional study is to compare the degree of variability between automated and manual processing of Quantitative Gated SPECT algorithms for assessing left ventricular volumes and ejection percent”. Study was carried out in the Nuclear Medicine department “at the Security Forces Hospital, Riyadh, Saudi Arabia, and comprised of 96 participants who “underwent” both stress and “rest gated” myocardial perfusion “imaging” (MPI) from February to May 2021. Data were analyzed “using SPSS for Windows (version 22; IBM Corp., Armonk, NY, USA). The mean of EF, ESV, and EDV on stress test using the automatic technique were 62.46 ± 14.62%, 45.00 ± 37.10 ml, and 107.01 ± 43.70 ml, respectively while using the manual technique were 57.21±14.80%, 44.35±35.93 ml, and 93.26±39.14 ml, respectively. The mean of EF, ESV, and EDV on rest test using the automatic technique were 62.85± 15.47%, 43.44± 36.35 ml, and 104.27±42.51 ml, respectively while using the manual technique were 57.74±15.33%, 43.30±36.42 ml, and 91.72±41.50 ml, respectively. For LVEF and EDV, the difference between automated and manual techniques is statistically significant (p0.05). Discrepancies were observed that exist by using the fully automated and manual technique for determining LVEF and Left ventricular volumes by gated MPI.
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