Original research. Рубрика в журнале - Cardiometry
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Aim. The purpose of the study was to reveal the effectiveness of the Cytochrome C drug in the early stages of the Pliss lymphosarcoma growth in white outbred rats. Material and methods. The studies were included white outbred male rats with an initial weight of 180–220 g (n = 40) with subcutaneously inoculated Pliss lymphosarcoma. Rats in the main group received the Cytochrome C intraperitoneally in a single dose of 1.6 mg/kg 1 hour after the tumor inoculation and then until death; animals with tumors in the control group received saline instead of the studied drug in the same way and in the same dosage. Results. Subcutaneous tumors appeared in the control group in 100% cases, in the main group in 55% cases; tumors were not detected in 45% of animals in the main group. In rats of the main group receiving experimental treatment, tumors regressed with time: in 73% cases with complete recovery of rats, in 27% cases animals died. Conclusions. The Cytochrome C in a therapeutic and prophylactic regimen had a pronounced antitumor effect. Perhaps the effectiveness of the drug can be improved using an inert carrier which will protect the protein from proteolytic cleavage when it enters the bloodstream, together with detoxification agents.
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The article analyzes the use of digital methods and artificial intelligence capabilities for diagnostics in the field of obstetrics and gynecology. The author notes that digital methods and artificial intelligence (AI) have a high potential for the diagnosis of gynecological diseases, since it can analyze medical images and other medical data with great accuracy and speed. For example, AI can help in the diagnosis of cervical cancer by identifying anomalies in digital images and screening tests. The use of AI can also help in the recognition of other gynecological diseases, such as endometriosis, uterine fibroids, polyps, etc. In addition, AI can help improve the efficiency and accuracy of diagnostics, as well as reduce the time required to process medical data. This can be especially important in cases where diagnosis needs to be done quickly in order to start treatment as early as possible. However, it should be noted that AI cannot completely replace the experience and expertise of doctors. Still, it can help doctors make more accurate diagnoses and develop more effective treatment strategies.
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Application of robotic systems in neurosurgery: problems and prospects
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The article discusses the features of the use of robotic systems in neurosurgery, as well as emerging problems and prospects in this area. The authors present an overview of the use of robotic systems in the field of neurosurgery, highlighting both current challenges and future prospects of this technology. The current state of neurosurgery is analyzed and a number of problems faced by surgeons are highlighted, including the difficulty of achieving high accuracy of exposure at the microscopic level, problems of access to deeply located or difficult to access areas of the brain, as well as the need to minimize potential risks for patients. The potential of robotic systems in solving these problems is also explored, and the advantages that robotic hardware and software complexes can provide are described in detail, including increased accuracy and predictability of surgical interventions, reduction of invasiveness of procedures, increased navigation capabilities inside the brain, and improved ergonomics for surgeons. In addition, the technical and organizational aspects of the introduction of robotic systems into the practice of neurosurgery are considered, which includes a discussion of equipment requirements, the integration of robotic systems into existing surgical practices, as well as aspects of training and training personnel to use new technologies.
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The precocious knowledge on reckoning schemes scientifically and technically was replaced with the rapid amelioration in medicinal contrivance systems and treatment information registers. On average the management accomplishes hospital information system (HIS) and picture archiving and communication systems (PACS) using digital entities to maintain medical examinations, images and statements. Such systems even though are much helpful for the hospital staff, doctor away from the hospital have lot of difficulty to access the patient data during risk facing situations. To iron out the above-mentioned complications, a new idea of the proposed framework has been disseminated for medical descriptions to the doctors at inaccessible areas. This organization requires a hand-hand PDA’s that adopts CDMA techniques with mobile networks. This arrangement requires a server and PDA for its implementation. This model supports the entire reports of the patient to the doctors located even at remote location with accessibility and doctor information reliable for patients. PDA created will disclose the inmate’s medicinal reports and scans over an outlying network. To corroborate or validate user data, remote data approach is applied by PDA that connects the server directory and for relegation of information from the server, uses file transfer protocol. From testing, observations show ninety seconds to convey thirty images with a fineness of 832 x 488, intensity of 24 bits and magnitude of 0.37 Mb. This idea proposed using bitmap image acquiring technique demonstrates no difficulty for distant doctors to collect and examine the sufferer images right away at the time of crisis or urgencies, which is completely subjective analysis based on doctor’s point of view.
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The absence of neoangiogenesis in the ischemic myocardium is the reason for the widespread prevalence of cardiovascular diseases. The mechanism is the age-dependent epigenetic blockade of the corresponding genes. In model experiments, it was shown that transfection of ischemic myocardium with plasmid vectors carrying the HIF1a, HIF1b, VEGF165, VEGF225 genes in a stoichiometric ratio of 1: 0.2: 0.5: 0.3, at a concentration of 400 μg / ml of physiological solution at a rate of 200 μg DNA per cm2 of ischemia zone and a step over an area of 2-10 mm, with the addition of an adjuvant2-dimethylaminoethanol at a concentration of 2.5 mmol / L, restores full neoangiogenesis. For the first time, it was shown that as a result of gene therapy of myocardial ischemia using four genes (HIF-1α, HIF-1β, VEGF 225, VEGF 165).In contrast to the known monotherapy methods, a complete vascular network is formed in the ischemic zone, having anatamoses with intact vessels. The scientific novelty of the study lies in the fact that the obtained data open the possibility of correction of epigenetic blocking of gene expression by transfecting cells with copies of these genes without epigenetic labels.
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Aim: Nurses’ and students’ willingness to increase information and practical skills through electronic platforms may help in setting up hundreds of timesaving and economical e-learning programs. The aim of this study is to evaluate the readiness of e-learning among different levels of nurses and nursing students. Methods: In this quantitative research, 425 participants from King Saud Medical City in Riyadh, Saudi Arabia were included. The study population included nurses and nursing students. Results: With p
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Background: Heart failure (HF) with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) exhibit distinct myocardial dynamics, which can potentially be modified by therapeutic interventions. This study aims to evalu ate the effects of sacubitril/valsartan on left ventricular myocardi al torsion mechanics in patients with HFrEF versus HFpEF.
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Assessment of system-related hemodynamics and tissue hydration in female patients with preeclampsia
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Hypertension disorders are reported to cover up to 10% of pregnancies in the world. It is precisely the arterial hypertension that is the leading cause of developing serious complications, long-term invalidation and high maternal and infant mortality rates. In the context of the maternal mortality, preeclampsia may be attributed to 25% of all lethal outcomes. Preeclampsia occupies the second place in the maternal mortality structure. Multifetal pregnancy is a risk factor for developing of preeclampsia. The given study has been designed to obtain main data measured in pregnant patients experiencing preeclampsia. The obtained data have been compared with parameters showing changes in intra-abdominal pressure (IAP) and biochemistry data in singleton versus multifetal pregnancies. Our study has shown that arterial hypertension in multifetal pregnancies may develop due to some factors not typical of preeclampsia pathogenesis. As a result, we may assume that establishing diagnosis Preeclampsia on the basis of arterial hypertention alone may involve an inaccuracy. Therefore, in making the proper diagnostics to differentiate between preeclampsia and other causes of arterial hypertension, it is reasonable to use some additional examination techniques like an impedance measuring method. The hemodynamic data collected therewith can be effectively used in selection of the most suitable hypotensive therapy and adjustment of infusion therapy.
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Assessment of the efficacy of a peroral anticoagulant after surgical resection of gastric cancer
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Aims Patients suffering from gastric cancer have a high risk of postoperative thrombotic complications and often use anticoagulants. Direct oral anticoagulants absorb in the proximal region of the digestive tract. Consequently, a reduction in anticoagulating activity is possible. In the present research given is an evaluation of the anti-Xa activity upon administration of Rivaroxaban at a fixed dose of 20 mg once daily in oncological patients after gastrectomy or cases of extensive resection of the stomach. Materials and methods The study cohort covered 20 patients after surgical treatment of gastric cancer having normal renal/hepatic function. The patients received Rivaroxaban at a fixed dose of 20 mg once daily to prevent venous thromboembolic complications.
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Introduction: Hypoglycemia is a clinical emergency that needs to be recognized and treated promptly to avoid organ damage and death. Knowledge of hypoglycemia prevention is an essential step in self-care practices due to the fact knowledgeable individuals are much more likely to practice hypoglycemia prevention. Prevention of hypoglycemia relies on adequate awareness and rightself-care. Objectives: To evaluate the level of knowledge and to self - care practice of hypoglycemia with their selected demographic variables among diabetic patients. Methods: A cross sectional descriptive research design was adopted with hundred samples who met the inclusion criteria in the hospital setting. Self-structured questionnaire method was used to acquire the data. Data have been through descriptive and inferential statistics. Result: Of 100 samples, 76(76%) had adequate knowledge and 63(63%)had good self-care practice on hypoglycemia. Spearman’s correlation showed positive relationship between knowledge and self-care practice of hypoglycemia (r value = 0.720, p
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The current study was done to isolation and indentification of the Staphlococcus aureus isolates associated with polycystic ovarian syndrome patients and determine the molecular status for these patients and bacteria. The study included 155 clinical samples, which were collected from November 2022 to June 2023. The samples included blood samples - vaginal swabs. About 75 samples were collected from women with polycystic ovarian syndrome (PCOS) and 30 samples were collected from women with polycystic ovarian disease ( PCOD). They visit Imam Al-Sadiq Hospital and Babylon Teaching Hospital for Maternity and Children in Babylon Governorate. While 50samples were collected from women without polycystic ovaries as a healthy group. All samples were cultured on different media for full bacteriological identification . In addition, blood samples were taken in order to studying molecular status. The results of this study on the polymerase chain reaction revealed a number of genes related to Staphylococcus aureus isolates and some of its virulence factors, including genes (mec A, spa, luks). The study revealed the presence of the mec A gene in 5 out of 38 isolates. And by (13.15 %). While the spa gene was present in 9 out of 38 isolates, with a rate of (23.68 %). While the luks gene was present in 7 out of 38 isolates, with a rate of (18.42 %). while the study included the genes of sick people by detecting some genes, including the study of genetic polymorphisms of the gene for cytokine IL13 in patient samples.
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Behavioral shift of generation X towards OTT during COVID’19 in India
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Over-the-top (OTT) services such as Netflix, Prime Video, Disney+ Hotstar, Zee5, etc., have changed consumers’ content consumption behavior. Globalization and Digitalization have encouraged consumers to have limitless access to the Internet for information, leisure, entertainment, and social interconnectedness. The increase in the availability of high-speed Internet, the latest smartphones, and breakthroughs in technology have created great opportunities for the OTT sector, with people preferring to consume content on-the-go digitally rather than traditional media services, such as cable television. The Covid’19 pandemic has seen an increase in viewership’s and subscriptions towards these streaming platforms, with people of different age groups adapting to changing viewership trends. This study aims to understand Generation X’s behavioral shift (Age 41 to 55) towards OTT during Covid’19 in India. The literature review talks about the Generation X cohort of consumers, their behavioral habits, and attitudes towards technology. It also discusses the changing trends of online content consumption and how Covid’19 has created a spark in viewership’s towards India’s online media services. The research study aims to perform explanatory research to establish a relationship between the increase in consumption and subscriptions of OTT services in India by Generation X and the impact of Covid’19 on the same. Data will be collected from consumer’s age amongst 41 to 55 in India via survey questionnaires, and linear regression tests will be performed to test the hypotheses and establish a correlation between the dependent and independent variables.
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Objective: In this study, copper oxide nanoparticles are produced using the probiotic Saccharomyces boulardii in order to assess their biological activity. The biological method of producing nanoparticles is gaining popularity due to its benefits over chemical and physical ways of synthesis in terms of affordability and environmental friendliness. Methods: To biosynthesize CuO NPs, copper sulfate was introduced at a concentration to S. boulardii’s cellfree supernatant. Results: The color change of the reaction mixture from light to dark after 150 rpm incubation, as well as the color change and antibacterial behavior, were indicators of S. bularedii’s biosynthesis of CuO NPs. The characterization completed by UV-visible spectroscopy, Atomic force microscopy, Energy Dispersive Spectroscopy, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, and X-ray diffraction (AFM). The CuO NP absorption spectra in the reaction mixture’s UV visible spectroscopy were (537.93 nm). The XRD showed that CuO NPs’ crystal size was (14.65 nm). The SEM was provided; the shape was uniform and spherical, and the average size (16.03 nm). EDS was used to analyze the presence of elemental CuO NPs. The CuO NPs’ three-dimensional structure was seen by the AFM, and their average diameter was (41.11 nm). The FTIR spectrum reveals a variety of functional groups that are present at various locations. Gram positive and gram negative bacteria that were isolated from diabetic foot infections were multidrug resistant (MDR), and biosynthesized CuO NPs demonstrated antibacterial action against these bacteria (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis). In the form of biofilm using a microtiter plate.
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Objective: Saccharomyces boulardii, a probiotic, is used in the current study’s manufacture of zinc oxide nanoparticles with the aim of assessing their biological activity. Due to its advantages over the chemical and physical techniques of synthesis in terms of affordability and environmental friendliness, the biological way of creating nanoparticles is becoming increasingly relevant. Methods: Zinc acetate was added at a dose necessary to biosynthesize ZnO NPs from S. boulardii’s cellfree supernatant (1 mM). Results: An evidence that S. bularedii was responsible for the reaction mixture’s color change from light to dark after 150 rpm of incubation was the color change and antibacterial behavior. Atomic force microscopy, scanning electron microscopy, energy dispersive spectroscopy, ultraviolet visible spectroscopy, and X-ray diffraction (XRD) all contributed to the completion of the characterisation (AFM). The spectra of the ZnO NPs produced in the reaction mixture using UV-visible spectroscopy were (343.75 nm). The XRD showed that ZnO NPs’ crystal size was (13.31 nm). The SEM was provided; the shape was uniform and spherical, and the average size (24.61 nm). EDS was used to analyze the presence of elemental ZnO NPs. ZnO NPs’ three-dimensional structure was seen using AFM, and their average diameter was (62.89 nm). The FTIR spectrum reveals a variety of functional groups that are present at various locations. Gram positive and gram negative bacteria that were isolated from diabetic foot infections were multidrug resistant (MDR), and biosynthesized ZnO NPs demonstrated antibacterial action against these bacteria. (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis). All of the studied bacterial isolates showed the ability to produce biofilms in the form of nanoparticle-treated biofilms on microtiter plates.
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Breast health is extremely important for all women. However, the breast is another region of the human body that is susceptible to cancer. Breast cancer is becoming increasingly common these days, and it is now one of the leading causes of mortality globally. According to the World Health Organization, breast cancer is the most common disease among women worldwide, claiming the lives of hundreds of thousands of women each year and impacting nations at all stages of development. In fact, it is the most common cancer in women, with a significant incidence observed among those aged 30 to 50. The goal of the World Health Organization’s Worldwide Breast Cancer Initiative (GBCI) is to reduce global breast cancer mortality by 2.5 percent each year; As a result, 2.5 million breast cancer deaths will be avoided globally between 2020 and 2040. To achieve these goals, three pillars must be in place: health endorsement for early detection, suitable identification at the right time, and comprehensive breast cancer management. Because of advances in early detection and care, the incidence of women dying of breast cancer has decreased by 41% from 1989 to 2018. During that time, more than 403,000 breast cancer deaths were prevented.
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COVID-19 pandemic: impact and opportunities for education in India
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The sudden breakout of COVID-19 has created a major crisis in almost every sector like Travel and Tourism, Entertainment, Sports, Corporates, Financials, Manufacturing, Education, and Service sectors. We cannot identify any sector which remained unaffected by the crisis. The magnitude of the impact may vary from sector to sector. The same happened to the Indian education system. It has faced a worldwide lockdown estimating to impact almost 320 million learners across the country. India has a robust education structure, with a huge chain of more than 1.4 million schools, 799 Universities, 39071 Colleges, and 11923 Stand Alone Institutions as per data available on the sixth report of ‘All India Survey on Higher Education on the web portal, are all affected by the pandemic situation. Our Indian education system was badly impacted due to pandemics, mostly based on traditional or classroom teaching. Though most of the school and colleges, for the benefit of students, had opted for online teaching, yet some of the low income private and government teaching institutes and students from a remote location could not opt to online teaching due to the unavailability of the internet, Laptop, Desktop or Smartphones persistent with a survey by EY-Parthenon.
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The aim of this research work is to study the cAMP level in the cardiac mitochondria and serum in the C57BL/6 strain mice of both genders under the independent melanoma B16/F10 growth versus the melanoma B16/F10 growth linked to chronic neurogenic pain (CNP). Materials and methods. Mice of strain C57BL/6 (n=336) have been grouped as follows: the intact group of the mice (♂n=21; ♀n=21), the reference group (♂n=21; ♀n=21) with the reproduced CNP model, the comparison group (♂n=63; ♀n=63) to include the mice with melanoma B16/F10, and the main test group (♂n=63; ♀n=63) to cover the mice with the melanoma growth against the CNP background. Upon expiration of 1 week, 2 and 3 weeks of the melanoma growth, in the animals of the above experimental groups the cardiac mitochondria have been isolated with the centrifugation using high-performance refrigerated centrifuge Avanti J-E, BECMAN COULTER, USA. With ELISA Kit (RayBio USA) we have determined cAMP concentrations in serum and in the cardiac mitochondria. Results. CNP has induced a decrease in the cAMP level in the cardiac mitochondria by a factor of 3,6 in the female mice only. In the animals of the comparison group the cAMP level in the heart has been increasing beginning with week 2 of the tumor growth on average by a factor of 4, while in the main test group starting from week 1 of the tumor growth it has been recorded 2-4 times higher and was depleted by the end of the experiment. As to the cAMP concentration in serum, the dynamics thereof has not been found to be in correlation with the cardiac mitochondrial data, and its concentration decrease has been recorded both in the females and the males. Conclusion. So, the changes in the cAMP concentration in the cardiac mitochondria demonstrate their gender-specific feature; the female mice as against the males have responded to an independent impact produced by CNP. As to the main test group, CNP has stimulated an increase in the cAMP level in the cardiac mitochondria 1 week earlier than it is the case with the comparison group, and it has resulted in the full cAMP depletion by the 3rd week of the experiment.
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Cardio-oсulometric indicators of psychophysiological readiness of students to examinations
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The article presents results of our experimental studies demon strating the techniques and methods of instrumental diagnos tics of individual preferences that the test subject intuitively at tributes to a number of significant factors of his/her personal success, as well as those role models, which are perceived by the test subject as the most appropriate description of his/her current state; some features of instrumentally recordable reac tions to specially selected stimuli are noted herein to provide additional opportunities for identifying the hierarchical system of vital goals and values of a person, a dispositional description of the structure of his/her actual needs.
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The article presents the experimental confirmation of the hypothesis that with the cardio- and oculometric assessment of various types of visual content, it is possible to conduct a selective analysis of the stimulus material used in projective diagnostics and identify a group of images most suitable for current consultation, and it also shows that there is often an increased interest in content that symbolizes the value of rivalry and risky forms of the behavior, with a high degree of probability, will correlate with the rapid manifestation of the respondent’s dissatisfaction with various kinds of restrictions on his/her behavior.
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