Статьи журнала - Cardiometry
Все статьи: 571
Accompanying transcranial magnetotherapy in combination treatment of high-grade glial brain tumors
Статья
Introduction. Low survival and poor quality of life in patients with high-grade brain gliomas (HGG) dictate the need to develop and promote new approaches, including accompanying transcranial magnetic therapy (TMT) with pulse-type magnetic field (PT MF) and ultra-low-frequency magnetic fields (ULF MF), characterized by their non-invasiveness and safety in applied procedures. The key point of these original wave technologies is the construction of algorithms of the actions based on the principles of activation therapy, which was developed as a result of the discovery “Pattern of development of qualitatively differing general nonspecific adaptational reactions of the organism” (Scientific Discovery Registration Certificate No. 158 issued by the Committee on Inventions and Discoveries at the Council of Ministers of the USSR, 1975).
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Статья научная
Aim The aim hereof is to study the glutathione system peculiarities in the cardiac mitochondria in experimental animals against the background of a tumor process, chronic pain and the combined effect both of chronic pain and the tumor process. Materials and methods The experiment has been carried out in female mice of the C57BL / 6 line (n = 28), aged 8 weeks, with an initial body mass of 21-22 g. The animals have been divided into the following groups: an intact group as the reference (n = 7), a test group with a reproduction of the chronic pain model (n = 7), a comparison test group (B16/F10), which covered the animals with standard subcutaneously inoculated melanoma B16/F10 (n = 7), and the main experimental group (chronic pain + B16/F10) of mice with B16/F10 melanoma inoculated 3 weeks after the chronic pain model development (n = 7). All rodents have been decapitated with a guillotine upon completion of 3 weeks of the experiment (on 21 day of the experiment). After decapitation, the animal hearts have been quickly removed with the use of coolants, and mitochondria have been isolated...
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Activation therapy: theoretical and applied aspects
Статья обзорная
The paper presents a brief review on how some concepts on the organism general adaptational reactions developed, including their role in increasing the unspecific resistance in the organism. Demonstrated is periodicity of the patterns of anti-stressor type reactions (training, calm and elevated activation) and stress in a wide range of stimulation values. The concepts on the organism adaptational reactions and reactivity levels have created the theoretical basis for practical applications of the activation therapy aimed at health improvement, prevention and treatment of various diseases, including oncology. Evidence data on the applications of the activation therapy as a promising approach to the organism state control are confirmed by the originators of this scientific discovery, their followers and medical experts.
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Acupuncture phenomenon of the QI energy complete awakening
Отчет
Aims The aim is to study the phenomenon of the Qi energy complete awakening using the acupuncture method and the reactions appearing during this process that lead to recovery of the body and of the cardiovascular system first of all. Materials and methods The study is based on the classical acupuncture method using the unique technique of effecting the points by I-Ching. Results The result is the body recovering the pathologic diseases the patient has been suffering for decades. Conclusion The new method for acupuncture is the Qi energy complete awakening based on structuring the Qi energy in the acupoints according to the figures of gua (trigrams and hexagrams) in the Chinese Canon of Changes and can be used for the treatment of almost any kind of the disease including cardiovascular. The given method allows not only balancing the Yin and Yang energy in the human body but also launching the generalized recovery program concentrated in the deepest layers of the human genetic memory. The given method allows treating many diseases considered to be incurable by the official medicine.
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Acute myocardial infarction following COVID-19 vaccination: a cause or a coincidence?
Статья научная
Background. Acute Myocardial Infarction (AMI) is a fatal condition with a subsequent variety of complications. Recently, COVID-19 vaccine has become an essential precaution to avoid infection. However, it is uncommon for AMI to manifest as a result of the COVID-19 vaccination. Methods. Thirty-two years old man, previously healthy, come to the emergency department with a four-hour history of chest discomfort after Covishield (AstraZeneca) vaccination. He was neither hypertensive, diabetic, or smoker and lacked any other typical risk factors for cardiovascular disease. Results. This case describes an adverse response to the COVID-19 vaccination that has the potential to be life-threatening. He had received his first dose of the Covishield vaccination five days prior. Extensive anterior STEMI was diagnosed post-cardiac arrest. He had primary percutaneous coronary intervention (PCI) to recanalize an occluded proximal LAD. Conclusions. Additional screenings for young individuals should be considered before administering the COVID-19 (AstraZeneca) vaccine as a preventive step if reports of significant adverse events in older adults continue.
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Adaptive reactions as a guideline in evaluation of metabolite therapy
Статья научная
Unilateral oophorectomy (UOE) of female rats caused severe stress with an increase in the duration of the non-reproductive period (NRP) - the metestrus and diestrus phases, and a shortening of the reproductive period (RP) - the proestrus and estrus phases in the estrus cycle (a symptom of hormonal deficiency). 5 weeks after UOE, the signs of stress persisted: a decrease in the ratio of lymphocytes to the neutrophilic leukocytes in the peripheral blood and the weight ratio of thymus to the adrenal glands, as well as a decrease in the activity of succinate dehydrogenase, which is determined cytobiochemically in peripheral blood cells. A two-week administration of a succinate-containing composition with B vitamins (SCCV) to control and UOE rats increased the ratio of lymphocytes to neutrophils and weight ratio of the thymus to adrenal glands above the intact level - a sign of the “activation” state according to Garkavi and Kvakina and restored the ratio of NRP/RP. At the same time, a significant increase in SDH activity was found in animal peripheral blood lymphocytes. The study demonstrates the possibility to reverse severe stress state to the “activation” state with the help of metabolic therapy containing the combination of SCC and B-Vit.
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Adhesive phytoadaptogens geroprotectors in preventive oncology
Статья научная
At the current stage of medical science development there is significant knowledge about various disorders in the tumor process (expression of oncogenes and cytokines, factors of apoptosis, drug resistance, angiogenesis, deficiency of immunoreactivity, etc.). Many of the identified features of the tumor cell are trying to be used as targets for anticancer therapy. However, it is problematic to consider these numerous “details” of the characteristics of a tumor cell as targets for anticancer therapy. This is due to the fact that they do not have a key or independent significance in the appearance of a tumor cell, although they can work in experimental animal models under certain conditions and with prolonged therapy, which at times has little relation to humans
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Статья научная
The role of adrenaline in the body, especially in athletes, is considered. Special attention is paid to the cardiovascular system performance in conditions of the continuous release of adrenaline. The ECG shape and the possible therapy in case of adrenaline heart are discussed.
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Отчет
Heart rhythm abnormalities are of critical importance for an assessment of risks of sudden cardiac death (SCD). “Disorders of heart rhythm are considered as a dynamic process of uninterrupted firing, existence and decaying of elementary sources, initiators of heart arrhythmias.”(Leo Bockeria) If it is a dynamic process, for its description we can use methods of non-linear dynamics that is aimed at time-related SCD risk prediction. This paper considers some issues connected with an application of a specific software module designed for an analysis of R/S amplitude alternation conditions that makes possible to restore the one-dimensional phase portrait of the dynamic system. Our idea is also to offer herein a method how to identify the optimum delay. We have developed methods for calculation of correlation and fractal dimensionality that makes possible to provide a sudden cardiac arrest prediction model.
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Age-related risk factors affecting the population morbidity
Статья научная
This article analyzes age-related risk factors that affect the population health. Risk factors that contribute to poor health are those that increase the likelihood of getting sick or injured. Risk factors are often presented individually, but it is confirmed that they are often interrelated in practice. For example, physical inactivity will lead to weight gain, high blood pressure, and high cholesterol over time. Together, they significantly increase the chance of developing chronic heart and other diseases, and the older a person is, the more various factors impact his health. The study aims to identify age-related risk factors affecting the morbidity of the population. The research was carried out using theoretical methods: the study of scientific articles, literature on the topic, and practical methods: observation and generalization. As a result, it was revealed what risk factors affect the population’s morbidity, the form and degree of their influence on humans, and methods for reducing the influence of these factors were proposed.
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Aging and active long healthy life in the context of chronobiology
Отчет
The challenge of aging and supporting active long healthy life of a human is treated herein in the context of the chronobiological theory of biosystem stability. An increase in the energetic efficiency of the structural regulation in the feedback and adapting process of a biosystem results in a reduction of its homeostatic capacity and inhibition of its biorhythms. The occurrence of pathological desynchronoses provokes further escalation of elimination of some elements in the biosystem and finally aging of the latter. The paper offers description of internal and external causes of desynchronoses and some methods of their removal by normalization of hierarchy of biorhythm periods.
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Algorithm for calculating blood pressure (BP) using a spline database of pulse waves
Отчет
Finding an algorithm for determining blood pressure (BP) along the pulse wave contour (PW) is the most difficult task after solving the problem of obtaining the most undistorted PW signal. Attempts to develop such an algorithm inevitably rest on the fact that the measurement of PV in the shoulder area using cuff tonometers (with the method by Korotkoff N. S. or Savitsky N. N.) differs in its physical nature from the cuff-free method of determining blood pressure using an arterial tonometer. However, the requirements for medical accuracy assume that the blood BP deviation tolerance shall be at least equivalent in comparison with the Korotkoff tonometer in accuracy tests regulated by the applicable international standard. In this regard, the computational procedures for processing the PW contour are continuously improved that is the subject of this paper.
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Статья научная
The Glasgow Coma Scale (GCS) is a widely used clinical tool for objectively measuring impaired consciousness in various acute medical and trauma conditions. This study aimed to explore the significance of assessing GCS knowledge among nurses. The research was conducted at PNS Shifa Hospital Karachi, situated in DHA Phase-II near Korangi Road Karachi, which provides training courses for medical professionals in the Pakistan Navy. The study employed a quantitative, descriptive crosssectional design. The findings of this study revealed that among the nurses at PNS Shifa Hospital, 63.33% possessed a high level of knowledge regarding GCS, while 35% had a moderate level, and only 1.67% had a low level of knowledge. Additionally, the study identified that nursing students at PNS Shifa Hospital exhibited varying levels of GCS knowledge, with up to 50% having a low level, 60 to 80% having a moderate level, and 80 to 100% demonstrating a high level of understanding. Furthermore, the study included demographic data indicating that out of the ttal participants, 20 were male and 40 were female nurses. In terms of age distribution, 40 nurses fell within the 20-25 years age group, while 20 nurses were between 26-30 years old. Moreover, the educational qualifications of the participants included 25 nurses with a General Nursing (GN) diploma, 2 with an advanced diploma after GN, and 38 with a Bachelor of Science in Nursing (BSN)/Post Navy and Allied Navies. This study highlights the importance of assessing GCS knowledge among nurses in the clinical setting. The findings underscore the need for targeted educational interventions to improve the understanding and application of the GCS scoring system, which serves as a crucial tool for decisionmaking and triage in assessing compromised consciousness levels.
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An innovative solution to the problem of hypertension
Статья научная
The results of the study of hemodynamic parameters in individuals of different age groups, the patterns of their age dynamics and the peculiarities of their influence on the formation of arterial hypo- and hypertension are presented. Based on the systematization of the profiles of systemic hemodynamics, clarifications in the pathogenesis of arterial hypertension are proposed. The rationale for an innovative approach to the choice of antihypertensive therapy, depending on the personal profile of hemodynamic parameters, is given.
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Analysis of immunohistochemical reactions of various PD-l1 clones in prostate adenocarcinoma
Статья
Prostate cancer (PC) is the most commonly diagnosed malignancy in men. The standard treatment for localized PC is radical prostatectomy, but recurrence is a significant problem in this case. The main prognostic markers of the disease recurrence are the Gleason score and the preoperative level of the prostate-specific antigen (PSA), which determines the need to identify some key molecules of the PC progression. This can be useful in identifying new prognostic markers or targeted treatments for this pathology.
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Analysis of methods for assessing threats in the field of data storage
Статья научная
At present, in the conditions of the active development of the information society, when information is the main means of production, special attention is paid to the methods and means of organizing its protection and storage. A large number of developments, both software and physical, are devoted to this issue. Cybersecurity is becoming more and more necessary every day and, as a result, popular, as a result of which a large number of specialists with a basic education in the field of information security graduate every year. In addition, an extensive regulatory framework has been developed that regulates the procedure and principles for protecting and storing data. Thus, we can talk about the existence of an entire industry aimed at maintaining and improving information security. Besides, it is proved herein that there is a need to develop a method for quantitative assessment of the security of stored data.
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Статья научная
Aims To overcome numerous contradictions in the knowledge of the blood transportation, a hypothesis was supposed asserting the swirling pattern of blood flow in the heart and main vessels which resembles tornado-like flows and which is widespread in nature. These flows can be exhaustively described by the exact solutions of the nonstationary hydrodynamic Navier-Stokes equations and the continuity equations for the class of viscous swirling flows offered by Kiknadze - Krasnov. Materials and methods Using morphometric studies of human and canine left ventricular casts and Multislice Computed Tomography it has been shown that the trabeculae in the ventricular cavity are oriented along the streamlines of the tornado-like flow of appropriate dimension. Moreover, this principle covers both the diastolic trabeculae of the inlet part of the left ventricle and the systolic trabeculae of the outlet part of the left ventricle. Results It is concluded that the main trabeculae function consists in the structural organization of the intraventricular tornado-like swirling flow of Kiknadze – Krasnov type. Conclusion The hydrodynamic analysis of the blood flow laws is indispensable for the development of new diagnostics criteria in cardiology, cardiac surgery optimization, the design of new implantable and paracorporal devices contacting with blood flow and mathematical and physical modeling of circulation.
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Analysis of the cardiovascular system performance in long living individuals
Отчет
The paper presents some interesting data and findings on the study of the performance of the cardiovascular system in long living individuals aged over 90. In this case, highland area individuals of this class are compared with those in flatland areas. For the purpose of the study, the cardiometric technology has been used that allows identifying age related features in the said long liver cohorts. The conclusions thereupon reveal the features of an individual age related state, the assessment of which may find practical applications by researchers involved in gerontology.
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Analysis of the infectious morbidity in the children's population in the city of Krasnodar
Статья научная
Aim. Our aim hereof is to assess the status of infectious morbidity in the pediatric population in the territory of the Russian Federation and the City of Krasnodar in the period 2021-2022 by an example of the State Health Institution “Pediatrics Polyclinic No 2”, Department of Health Care of the City of Krasnodar. Material and Methods. Our work has been completed with use of official statistical data of the Federal Service of the state statistics of the Russian Federation, the database of Rospotrebnadzor of the Krasnodar territory, statistical data set collections of FGBI “The Central Research Institute of the Management and Information of Public Health Care” at the Ministry of Health Care of the Russian Federation. A retrospective analysis was performed using data from the State Report “The state of sanitary and epidemiological welfare of the population in the Russian Federation in 2021”. Statistical processing was carried out using GraphPad Prism 5.0 and Word Excel. Results. According to the data on the sanitary and epidemiological well-being of the population, an increase in the number of cases of infectious and parasitic diseases was recorded in the Russian Federation in 2021. The sharp rise in the incidence of infectious diseases is directly related to the spread of the new COVID-19 infection. The incidence of ARVI among children in 2021 was 68,062.49 per 100,000 that is 15.4% higher than in 2020. In Krasnodar, there were 236,332 patients diagnosed with infectious diseases in 2021. According to the data submitted by Branch No. 2 of the Krasnodar City Pediatrics Hospital at the City Health Care Department, the overall morbidity of children in the first year of life in 2022 has decreased. No cases of diphtheria, pertussis, poliomyelitis, measles, and viral hepatitis B were recorded by the outpatient clinical institution during the study period. As a part of preventive measures, children are routinely vaccinated by the Pediatrics Hospital No. 2; at the end of 2022, 98.3% of children in risk groups had been successfully treated and were allowed to be vaccinated. Conclusion. Over the period 2021-2022, there has been a decline in the incidence of diseases in children in the first year of life in the Krasnodar Region. At the same time, the recorded overall occurrence rate of acute upper respiratory tract infections of multiple and unspecified localization remains high that is due to the difficulty of diagnosing them at the early stages of infection, and, as a result, the effectiveness of their treatment is low that may be accompanied by high mortality.
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Analyzing the impact of COVID-19 on the hotel industry in Nepal
Статья научная
COVID-19 pandemic has significantly affected the tourism and hospitality sectors across the globe. Due to the increase in the number of COVID positive cases, governments of countries have imposed strict lockdown globally as a precautionary measure to control the spread of the coronavirus, which has led to restrictions on travel and mobility of individuals from one place to the other. One of the countries that have been severely affected due to the lockdown is the economy of Nepal. Being a tourist-friendly nation, every year, Nepal’s tourism and hospitality sector contributes significantly to its GDP. With a restriction on travel and cancellation of bookings, one of the most important departments under this sector, the hotel industry, is currently struggling to survive due to loss of revenue. The present study tries to understand the challenges and strategies planned by the hotel industry stakeholders in Nepal. A primary survey conducted with hoteliers from 10 hotels reveals major concerns about maintaining a steady financial performance and expectations for government aid to help this sector come back to normalcy.
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