The goals of this prospective observational study were to identify quantitative morphological factors that might aid in the prediction of PBMV outcome, as well as to define the function of 3D TEE in mitral valve evaluation. Material and Methods: The trial comprised seventy individuals who had isolated severe rheumatic Mitral Stenosis (MS) who were scheduled for PBMV between October 2017 and March 2021. Trans-thoracic echocardiography (TTE) was used for pre-procedural evaluation. Posterior to Anterior Leaflet Length Ratio (P/ALLR), Commissural Area Ratio (CAR), Doming Height (DH), and Calcification Score (Ca score) were also assessed using 2D and 3D-Trans-esophageal Echocardiography (TEE). Following that, all patients were monitored for three months. Results: We have had 50(71.5%) successful procedures and 20(28.5%) unsuccessful procedures. The additional parameters showed highly significant difference between successful and un-successful groups (P-value 0.6 and >0.55 by 2-D and 3-D TEE respectively, CAR ≤ 1.28 and ≤ 1.25 by 2-D and 3-D TEE respectively, DH > 1.2 cm by 2-D TEE, and Ca Score ≤ 2. Conclusion: In our research, we discovered that these characteristics may predict the result of PBMV and contribute value to the semi-quantitative methodologies we adopted to use.

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Impact of COVID-19 on the Mental Well-Being of Employees: A Study of Mental Wellness of Employees during COVID-19 in India

Samridhi Bhandari, Lavina Sharma

Статья научная

COVID-19, which also induced an economic downturn globally, has forced the organizations to suddenly implement remote working, creating many challenges for the employees. The fast spread of the virus may also create fear among the employees. It can have a detrimental impact on the mental well-being of employees. There exists inadequate research on this subject, which is not only new but also very important. The study aims to assess the impact of a sudden transition to remote working, economic downturn, and the fear of virus transmission on the mental well-being of employees in India, focusing on the triggers of anxiety & mental illness. The impact of anxiety-causing independent factors, including organizational support, worklife balance, isolation, fear of the virus, and recession, on mental well-being, was determined through a survey. The dependent factor, i.e., the severity of anxiety, was measured using GAD-7 questions. The independent factors were measured through structured questions. Statistical analysis of the data was carried out on SPSS. There were no significant differences in gender between severities of anxiety. Logistic regression revealed that Organizational Support significantly influenced the anxiety of employees. It was found that there exists a significant association between the severity of anxiety in Employee Assistance Program, Job Insecurity, Financial Impact, and Fear of getting the virus, Concern over Safety at Workplace, Home Environment and Deterioration in team collaboration

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Impact of exercise on the activity of the autonomic nervous system among patients with acute myocardial infarction: a case-control study

Rafsanjani Pour M.H.A., Moghadam S., Afsargharehbagh R.

Статья научная

Considering the diversity of proposed programs, various studies yielded different findings in this regard. The aim of the present study was to evaluate different types of exercise as a method of rehabilitation after acute myocardial infarction on the activity of the autonomic nervous system.

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Impact of inclusiveness on organizational commitment among employees of IT industry

Saha T., Bhattacharya S.

Статья научная

Organizations continue to be challenged by diversity in their workforce. Hence it becomes imperative to nurture an inclusive workplace where all employees can co-exist and thrive. The primary objective of the current study is to examine the relationship between different constructs of inclusiveness and the organizational commitment of employees. Their search for the study is based on the data collected from multiple IT organizations across major cities (Delhi, Mumbai, Bangalore, and Pune) of India. A structured questionnaire was distributed. Multiple regression analysis was applied on the primary data obtained from 160 respondents to interpret the impact on the organizational commitment by different constructs of inclusiveness. The results from the study reveal that different constructs of inclusiveness (supervisor role, relationship with co-workers, and organizational practices) have a significant effect on the organizational commitment of an employee. The study highlights the importance of creating a sense of acceptance among employees of an organization through inclusive work culture, which ultimately enhances the commitment level of employees towards their organization.

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Impact of the academic performance grades on the blood picture in female students

Anzorov V.A., Moryakina S.V.

Статья научная

The paper presents the blood picture patterns in female students with different average academic performance grades in their record book. An improvement in the academic performance of female students is accompanied by a significant decrease in the concentration of neutrophils, a significant increase in the level of lymphocytes and minor changes in other blood parameters. Thus, the level of neutrophils experiences a gradual decrease, reaching its minimum of 57.7% (P

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Impact on student behavior due to COVID-19 lockdown in India

Singh J., Chitranshi J.

Статья научная

This paper aims to comprehend the change & impact on students’ behavior during the COVID-19 Lockdown in India. The research is conducted by surveying to assess the different behavioral changes due to the COVID-19 spread. Novel coronavirus pandemic started from Wuhan, China, on 31/12/19. It spread across the globe affecting 1,00 000 people within the span of two to three months. People across the globe were affected not just in terms of physical health but also mental & psychological health, resulting in major changes in their behavior. The digital questionnaire assessed the status of pupils’ mental and psychical nature while the COVID-19 lockdown was on. The questions were framed to answer how students felt about the pandemic and how it has affected their day-today life. The results of the survey revealed the measure of the anxiety level of the students. The survey results are analyzed on SPSS, and Pearson Coefficient is the method used for statistical analysis. The survey results revealed that 74.2% of the respondents favored cleaning their hands more often due to the COCID-19 pandemic. In the same way, an overwhelming number of student respondents have become aware that wearing masks is crucial to prevent the spread, and 95.9% of student respondents have favored wearing masks if they decide to step outside of their house. Student respondents are more worried about the possibility that their family members will catch the COVID-19 virus than the concern of themselves catching the virus. The student respondents showed clear signs of worry and unpredictability due to the COVID-19 spread. More than have 37.6% have responded that they are in a constant state of worry during the lockdown. The paper states varied responses from the students on the anxiety levels and that they have been experiencing high anxiety levels during the lockdown. The measurement and correlation between emotional & preventive behavior can provide viable options to reduce the outbreak and further control it.

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Implementation of the principles of activation electromagnetotherapy in experimental oncology

Zhukova G.V., Shikhlyarova A.I., Sheiko E.A., Gudtskova T.N., Zernov V.A., Rudenko M.Yu.

Статья

Introduction. Identification of an important mechanism of homeostasis associated with the existence of a periodic system of general nonspecific adaptational reactions of the body (AR) [1-3] as well as the study of the conditions for the development of the anti-stress AR of high levels of reactivity as the most favorable AR for an organism, allowed determining the requirements for the parameters of external regulatory actions, acting factors and regimes of their application. As a result, the principles of activation therapy (AT) were formulated: it is a treatment technology aimed at the physiological mobilization of the mechanisms of general nonspecific (including antitumor) resistance of the body. Among the AT factors, one of the leading places is occupied by electromagnetic radiation (EMR), which has a wave nature, to which the CNS structures as well as regulatory and metabolic processes of lower levels are highly sensitive [1, 3].

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Influence by hypothyroidism on the level of sex hormones in blood and their intracrine content in the tumor in rats with Guerin's carcinoma

Kit O.I., Bandovkina V.A., Frantsiyants E.M., Kaplieva I.V., Shikhlyarova A.I., Surikova E.I., Neskubina I.V., Cheryarina N.D., Pogorelova Y.A., Trepitaki L.K., Arakelova A.Y., Maksimova N.A., Poryvaev Y.A., Ilchenko M.G.

Статья научная

The aim of our research work was to study the level of sex steroids in blood, the tumor and the perifocal zone in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. The experiment was performed in 110 outbred rats of both sexes. Hypothyroidism was induced in animals for 30 days with Mercazolil medication, and then Guerin’s carcinoma was transplanted (the main group). The reference groups included animals with an independent growth of Guerin’s carcinoma and with independent hypothyroidism, as well as intact animals (the norm). On the 18th day of the tumor growth, the animals were sacrificed, and, using standard RIA kits, in the serum, the tumor homogenates and the perifocal zone, the levels of estradiol (E2), testosterone (T) and progesterone (P4) were determined. Results. In comparison with intact animals, hypothyroidism caused an increase in the blood content of E2 in animals of both sexes by 2.2-2.4 times and T by 1.4-16 times, and P4 by 1.7 times only in females, but recorded was a decrease therein in males by 2.4 times. The growth of Guerin’s carcinoma resulted in a 2.5-5.5-fold decrease in E2 in blood of the animals of both sexes, an increase in T by 2.1 times and P4 by 3 times in the females, but a decrease in T by 2.6 times without changing P4 in the males. In the main group, in the animals of both sexes, similarly to the processes in hypothyroidism, the level of E2 and P4 increased by 1.4-1.6 times, and in females also T by 4.4 times, compared with the intact animals. Conclusion. Hypothyroidism and the growth of Guerin’s carcinoma changed E2 in different directions in animals of both sexes the level of sex hormones in blood and shifted the steroid balance in the tumor and its perifocal zone. In the females of the main group, the saturation of the tumor with estrogens, androgens and progesterone decreased, while in the males, on the contrary, the concentration of steroids increased.

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Influence made by industrial climbing safety equipment on the cardiovascular system performance and thermophysical parameters of limbs in an industrial climber at low ambient temperatures

Maria A. Goncharova, Ivan Y. Brink

Статья научная

The task of the article is to assess the effect made by an industrial climbing safety system used by an industrial climber, performing his work to provide a harness-based suspended access at low ambient temperatures, on his physiological parameters. The article presents some studies on changes recorded in body surface temperatures, pulse rates, and blood pressure value in an industrial climber depending on the duration of his performance using a harness-based suspended access under ambient air low temperature conditions. The tests have been carried out for various types of thermal protection of the human hip area and the width of the belts of the safety system. The scientific novelty of the study is that it is the first time when such a study has been conducted for a combination of industrial factors, like prolonged suspended condition due to the utilization of the climbing safety system and a low ambient temperature. As a result, it has been found that the physiological parameters are influenced by the width of the safety belts of the safety equipment system and the method of the temperature protection of the hip zone in a climber.

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Influence of acupuncture on the phase characteristics of the cardiac cycle in the process of treating the patients with cardiovascular system pathology

Skakov Victor, Rudenko Mikhail, Zernov Vladimir

Статья научная

Aims The response of the cardiovascular system to acupuncture treatment is studied in the present paper. Materials and In the process of study a special device for recording hemodynamic methods parameters as well as the classical acupuncture method was used. The hemodynamic parameters were recorded at the time of needle insertion, during the acupuncture session and after the session. Results The changes in the phase blood volumes were recorded. The influence of the acupuncture on the muscle contraction amplitude during all phases of the cardiac cycle was recorded. Conclusion Appliance of the cardiac cycle phase analysis enables accurate monitoring of the response of the cardiovascular system to acupuncture.

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Influence of diabetes mellitus on free radical processes in the heart in rats with Guerin's carcinoma and characteristics of malignant lesions depending on the gender of animals

Kit O.I., Frantsiyants E.M., Goroshinskaya I.A., Kaplieva I.V., Shikhlyarova A.I., Nemashkalova L.A., Trepitaki L.K., Kachesova P.S., Bykadorova O.V., Serdyukova E.V., Maksimova N.A., Ilchenko M.G., Akopian L.G., Agarkova E.I., Sergeeva M.M., Kotieva I.M., Morozova M.I.

Статья научная

To study the intensity of lipid peroxidation (LPO) and the activity of the main antioxidant protection enzyme: superoxide dismutase (SOD) in heart tissues and tumors in rats of both genders with Guerin's carcinoma (GC) and the tumor growth against the background of diabetes mellitus (DM). Materials and methods. Our research work was carried out in 80 outbread albino male and female rats, divided into 4 groups, with 10 animals of each gender in a group. The animals of two groups, namely, an intact animal group and a group of rats treated with alloxan DM (with a 5-fold increase in glucose levels) were subcutaneously transplanted with the Guerin's carcinoma (GC) strain cells, and at the same time we used one group of the intact rats and another group of the animals with DM as the references. The content of malondialdehyde (MDA), diene conjugates (DC), and the SOD activity in the heart and the tumor tissues were determined by conventional spectrophotometric methods. Results. The most pronounced changes were found in the heart in the female rats with isolated GC and GC growing against the background of DM: a more than threefold increase in MDA, with a significant increase in DC and a multiple increase in the SOD activity as compared with the intact animals. In the GC tissue, the dependence of the severity of the increase in the MDA content on the size of the tumor was traced: the maximum increase in both parameters was observed in males with GC tumor growing against the background of DM. In the males, the volume of the subcutaneous tumor nodes was 1.8 times greater than that in the reference group and in the females with combined pathology, while in the females with combined pathology the volume of their tumors was 1.3 times less than that in the reference group, although the area of tumor lesions in them was maximum due to extensive metastasizing. Conclusion. DM has changed the specifics of oncogenesis depending on the gender of the animals. The identified gender differences in the redox status of the heart and the tumor in rats with combined pathology contribute to specifics of oncogenesis in males and females and determines their life expectancy.

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Influence of hypothyroidism on the hypothalamic-pituitarygonadal axis in rats with Guerin's tumor

Frantsiyants E.M., Bandovkina V.A., Kaplieva I.V., Surikova E.I., Neskubina I.V., Trepitaki L.K., Shikhlyarova A.I., Goroshinskaya I.A., Zhukova G.V., Nemashkalova L.A., Popov I.A.

Статья

The thyroid and the gonadal (HPG) regulatory axes are interconnected and act together as a single system and their imbalance leads to pathological responses of the organism [1, 2]. The involvement of thyroid and sex hormones in the development of the malignant process has been discussed for many decades.

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Influence of postoperative magnetotherapy on homeostasis central regulation efficiency

Protasova Tatiana P., Shikhlyarova Alla I., Korobeinikova Elena P., Barsukova Lyudmila P., Airapetova Tatiana G., Arapova Yulia Yu., Rostorguev Eduard E.

Отчет

Aim The aim of the present research is to study the dynamics of bioelectric markers of the CNS functional state in lung cancer patients during an early postoperative period for the purpose of evaluation of the conducted magnetotherapy adaptive and correcting effects. Materials and methods 25 lung cancer male patients have been examined. The reference group patients received a standard postoperative therapy, while in the main group it has been accompanied by the complex modulated ultra low frequency magnetic field exposure applied to the occipital area. Before the operation and 10 days after it in all the patients EEGs have been recorded unipolarly, according to system “10/20” as well as the galvanic skin resistance measured in reference points using the R. Voll electro-acupuncture method. Results It is demonstrated that the postoperative magnetotherapy application in lung cancer patients is accompanied with a significant exceedance of the spatial synchronization values over the corresponding markers only in case of surgical treatment: in alpha band between the central and temporal area in the left hemisphere, and between the similar areas in the right hemisphere; in beta-band between the symmetrical areas in the temporal and central cortex...

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Influence of standard and stimulated growth of B16/F10 melanoma on AIF levels in mitochondria in cells of the heart and other somatic organs in female mice

Kit O.I., Frantsiyants E.M., Neskubina I.V., Cheryarina N.D., Shikhlyarova A.I., Przhedetskiy Y.V., Pozdnyakova V., Surikova E.I., Kaplieva I.V., Bandovkina V.A.

Статья научная

studying AIF levels in mitochondria in cells of the heart and various organs in female mice with the growth of experimental melanoma B16 / F10 and comorbid pathology

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Influence of urokinase gene knockout on level of prekallikrein and kallikreins 1 and 14 in mice with melanoma growth against the background of pain

Frantsiyants Elena M., Surikova Ekaterina I., Bandovkina Valeriya A., Kaplieva Irina V., Neskubina Irina V., Cheryarina Natalia D., Pozdnyakova Viktoria V., Kit Oleg I.

Статья научная

The aim is to study the content of prekallikrein, kallikreins 1 and 14 (KLK-1 and KLK-14) in mice under the conditions of activation and inhibition of the B16/F10 inoculated melanoma growth. Materials and methods We produced a model of chronic neurogenic pain (CNP, bilateral ligation of sciatic nerves) and a model of the B16/F10 melanoma growth against the background of CNP using female/male mice of the C57BL/6 line (with normal genome, n=75) and the C57BL/6-Plautm1.1bugthisplaughfdhu/GFDhu line (with urokinase knockout (uPA), n=46). The ELISA method was used to determine the content of prekallikrein, KLK1 and KLK14 in the tumor and skin after 3 weeks of carcinogenesis against the background of CNP. Results The initially high content of prekallikrein, KLK-1 and KLK-14 in the skin of intact knockout mice was found. When inhibiting the growth and metastasis of melanoma in the skin of the knockout females, noted was a further increase in the initially high level of prekallikrein and KLK1, and in the tumor in the knockout mice of both genders recorded was a lower content of all the studied enzymes. When activating the growth of melanoma in the state of CNP in the skin of C57BL/6 mice, the level of KLK1 (female) decreased and the concentration of KLK14 (female and male) increased; in the knockout mice the content of prekallikrein and KLK14 decreased, and KLK1 changed multidirectionally. The tumor demonstrated a lower prekallikrein level in all C57BL/6mice and multidirectional changes in KLK1 and KLK14 in females and males. The tumor in the knockout animals showed a lower content of all the studied enzymes, especially pronounced for KLK14. Conclusion The content of prekallikrein, KLK1 and KLK14 varies under activating and inhibiting the growth of melanoma, the changes are of the gender-specific type. It is probable that the functions of the studied enzymes in the skin change not only in case of CNP, but also in case of urokinase deficiency. The tumor itself adapts the performance of the kallikrein-kinin system depending on the metabolic features of the tumor-bearing organism.

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Inhalation health risk assessment of some of heavy metals for kerosene samples in Iraq market

Wadi Sattar Nema, Pasha Mohammad Akbarzadeh, Abojassim Ali Abid

Статья научная

In this study, five heavy metals (Zn, Fe, Pb, Cu, and Cd) concentrations were measured in samples of kerosene (locally only) that collected from different of warehouses oils in Iraq. The measurements have been done using Atomic Absorption Spectrophotometer. Non-cancer risks such as the chronic daily inhalation intake (CDIinh), a Hazard Quotient (HQ), and Haz-ard Index (HI) as well as Cancer Risks (CR) due to inhalation of heavy metals in the kerosene samples were calculated. The results show that, the average values of concentrations in unit ppm (mg/kg) belonging to Zn, Fe, Pb, Cu, and Cd in kerosene samples were 8.14±1.74, 0.127±0.025, 0.017±0.007, 0.15±0.064, and 0.360±0.022, respectively. While, the average value of Haz-ard Index (HI) due to all heave metals in the present work was 0.721± 0.16. Also, the average value of Total Cancer Risk (TCR) due to Cd and Pb were 1.12E-03±4.4E-04. When comparing the results of inhalation health risk, the present work with Worldwide average, we found that the most samples of kerosene samples are safe for using.

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Innovations in laparoscopy: current trends and prospects for the development of surgical techniques

Noskova E.M., Darmina S.N., Zubairaeva A.R., Tlupova I.Z., Gabuev E.O., Khabibulla E.A., Tserr A.E., Bashmakova N.S., Mytnik E.E., Baiandurova L.S.

Статья научная

The article examines current trends and prospects for the development of surgical techniques in laparoscopy with an emphasis on innovation. The latest technologies and methods used in laparoscopic surgery, such as robotic surgery, improved video systems, three-dimensional visualization and telemedicine solutions, are highlighted. The authors analyze the benefits of these innovations, including more accurate and effective procedures, shorter patient recovery time, and reduced risk of complications. The challenges facing the introduction of new technologies, including the need for staff training and the high cost of equipment, are also considered. It is concluded that innovations in laparoscopy play a key role in modern surgery and have the potential to significantly improve patient outcomes in the future.

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Innovative approaches to development of geroprotectorsphytoadaptogens for preventive oncology and age-related pathologies

Bocharova O.A., Karpova R.V., Bocharov E.V., Aksenov A.A., Chulkova S.V., Kucheryanu V.G., Kazeev I.V., Revischin A.V., Pavlova G.P., Shevchenko V.E., Sheichenko O.P., Ionov N.S., Kosorukov V.S., Poroikov V.V., Matveev V.B., Stilidi I.S.

Статья

At the present stage, the problems of preventive oncology are becoming more and more important, especially, at the stages of blastomogenesis, recurrence and metastasizing of tumors. Preventive measures can also be aimed at regulating the stress syndrome, improving the efficiency and safety of chemoradiotherapy, and improving the quality of life and rehabilitation processes for cancer patients. Promising in this aspect are approaches, which take into account the unique capabilities of natural antitumor geroprotectors: phytoadaptogens (PhA)

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Innovative technologies for the treatment of cervical intraepithelial neoplasia of the cervix

Kattakhodjaeva M.Kh., Karshieva E.E., Amonova Z.D.

Статья научная

The problem of pathological conditions of the cervix attracts great attention of doctors of many specialties, which is due to the ambiguity of the prognosis of this pathology. The detection of gynecological pathology, including cervical pathology, depends on the use of screening diagnostic methods, improvement of preventive and therapeutic measures carried out in an outpatient setting. In modern medical practice diseases of the cervix uteri occupy a leading position due to the high the frequency of their occurrence, frequent transformation into precancerous conditions, which in turn can be the cause of cervical cancer. Today, both in world practice and in Uzbekistan in the structure of oncological diseases of the genital organs in women cervical cancer is the second most common disease, causing high mortality of patients.

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