Статьи журнала - Cardiometry
Все статьи: 571
Medicinal plants containing alkaloids: prospects for their use in oncology
Статья
The aim of our study was to search and identify new promising plant species containing alkaloids in order to develop new effective herbal medicines for antitumor therapy.
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Metabolic processes evaluation in cardiac muscles on the basis of cardiometry
Отчет
he article briefly discusses the cardiometric approach to the evaluation of metabolic processes in cardiac muscle. Reactions occurring during the various phases of the cardiac cycle, primarily in the QRS complex, are shown. The dynamics of energy processes occurring before and after physical load, as well as the reactions occurring during it, are presented. The ECG derivative is used
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Статья научная
The paper discusses a new method for diagnosing atherosclerosis using a pneumatic arterial blood pressure sensor previously developed by the authors hereof. The possibility of applying a pneumatic sensor to measure the pulse wave transit time referring to a synchronous ECG is treated herein. The specification of the method consisting in the selection of the characteristic moment of the pulse wave as the timestamp, when measuring the signal transit time in relation to the R-peak of the synchronous ECG, is justified hereby. The averaged values of the wave transit time at different points of the artery, taking into account the variability of the front delay values, are used to directly determine the pulse wave propagation velocity in the area between the measurement points.
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Статья научная
The relevance of the research work lies in the fact that a significant number of surgical patients are at risk of intra or postoperative complications, or both, which is associated with prolonged stay in the hospital, costs and mortality. Reducing these risks is important for each individual patient, as well as for health care planners and managers. Insufficient tissue perfusion and cellular oxygenation due to hypovolemia, cardiac dysfunction, or both, are one of the primary causes of perioperative complications. Adequate perioperative management, guided by effective and timely hemodynamic monitoring, can contribute to a reduction of the risk of complications and thus potentially improve outcomes. This article discusses the technique of visualization of the cardiovascular system during the study of patients with perioperative myocardial injury. The purpose of this article is to identify ways to reduce the risk of complications using a specific technique for imaging the cardiovascular system during the study of patients with perioperative myocardial injury. The practical significance of the article implies that the results of the research can be used in the work of medical staff responsible for monitoring patients with myocardial injury in the perioperative period. To determine the most effective imaging technique for the cardiovascular system, an analysis of the existing imaging techniques, their advantages and disadvantages was used.
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Methodological basis of the relationship between art and medicine
Статья научная
The aim of the article is to show the importance of methodological foundations in the relationship between art and medicine, whose source is the sacral core of the syncretic complex of primitive society, which includes the principles of harmony and beauty, the use of which makes it possible to have a therapeutic effect on human health under conditions where modern art of the West and East is characterized by the use of many new technologies that cancel the lines between abstract thinking and artistic activity. All this is directly related to the functioning of medicine III, which combines the methods of Eastern and technology and the instrument base of Western medicine, as well as new concepts and paradigms in the context of such trends of the modern world as aestheticization and technization.
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Отчет
A unified approach to the problems of health preservation in athletes, taking into account the options for phenotyping their health and basing on the main indicators of homeostatic potential, makes it possible not only to diagnose the initial functional disorders of the organism and monitor its basic capabilities, but also maintain the current functional reserves of the athlete at the proper level. This is provided by the use of a diagnostic and recovery unit, the recovery component of which forms complex medical and biological effects: it improves central and peripheral hemodynamics and increases the energy supply of cellular structures, i.e. increases the energy supply of the athlete's organism as a whole. This is the main component of the stability in training athletes of various kinds of sports.
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Methodological fundamentals of experimental magnetotherapy of tumors (historical essay)
Отчет
The paper highlights the key stages on the way of a proper understanding of the magnetic field anti-tumor influence mechanisms on the level of an organism as an integrated system and its individual subsystems. The experiments in animals have shown that the processes of the malignant tumor growth inhibition are closely related to the formation of the stable state of the activation reaction at high reactivity levels. It is noted that the induction of such adaptational reaction depends on a specified selection of parameters of exposure intensities and magnetic field frequency, taking into account the law of nonlinearity of an exposure effect and adequacy with endogenous rhythms.
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Ред. заметка
The article provides the methodology that allows coaches, doc-tors and other staff members to comprehensively assess the athlete's conditioning, control the level of fitness and correct the physiological state. The methodology is based on the theory of cardiometry. The data for assessment is taken from the ECG recorded with only one lead from the ascending aorta. It is an original concept of the methodology. The aortic ECG record is capable of delivering the total result of the heart's performance that makes possible to comprehensively evaluate the athlete's conditioning. The relationship between the heart performance and the central nervous system operation is also indicated.
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Methods and tools for three-dimensional cardiac modeling
Статья научная
This article explores the use of methods and tools for three-dimensional modeling of the heart with computer-aided design systems. The use of three-dimensional modeling in medicine is a very pressing scientific and engineering problem. The object of study of this work is the process of three-dimensional cardiac modeling with CAD, and the subject of research is methods and means of three-dimensional modeling of the heart. This publication also provides the key elements required to create a 3D computational model of the heart for biophysical modeling. The article discusses some of the difficulties that arise at various stages of developing 3D cardiac modeling. The approaches which are currently available for three-dimensional computer modeling of the heart are briefly described herein.
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MicroRNA MIR-204-5P is a regulator of apoptosis in dacarbazine-resistant melanoma cells
Статья
Therapy for skin melanoma in its disseminated form is ineffective, among other things, due to the development of tumor cell resistance, mediated by various mechanisms. The acquisition of a stable cell phenotype is associated both with genetic and epigenetic changes mediated by the regulatory non-coding microRNA molecules. The aim hereof is to investigate the ability of microRNA miR-204-5p to influence changes in the cell cycle and apoptosis of melanoma cells resistant to the chemotherapeutic alkylating agent dacarbazine, used in standard chemotherapy for melanoma.
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Microgravity: an ideal environment for cardiac force measuring
Отчет
In the article main principles of ballistocardiography are considered. Special attention is paid to registration of the spatial ballistocardiogramm. There exist two principles of ballistocardiography: dynamic and seismic. In the event of dynamic ballistocardiography body displacements align to an extent with shifting of the general center of body gravity. Ideal conditions for ballistocardiogram acquisition could be reached if rigidity of internal body relations had an infinitely large value, while rigidity of external relations was nearing the zero. Then displacements of the entire body would depend only on the forces imparted by the cardiovascular system. Microgravity is the only environment providing these ideal conditions for ballistocardiography. Microgravity allows effective application of the dynamic BCG principle to recording pulse-induced body movements corresponding to the center of mass displacements. This kindled interest of the first researchers in space medicine in ballistocardiographic investigations during space flight...
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Mitochondrial dysfunction under the growth of B16/F10 melanoma in C57Bl/6 mice
Статья
Mitochondria are present in all organs and tissues of the organism being responsible for the control of various aspects of the cellular function, providing the necessary supply of ATP, regulating Ca2+ signaling, controlling levels of reactive oxygen species (ROS) etc. Mitochondria perform specialized functions unique to certain tissues. Abnormalities in mitochondria disorder the key physiological functions such as the ATP production, oxidative phosphorylation, the reactive oxygen species production, and the Ca2+ regulation. This is considered as the mitochondrial dysfunction [5]. It is known that tumor mitochondria undergo some adaptive changes to further accelerate the rapid reproduction of tumor cells in an acidic and hypoxic microenvironment [2]. Aims. The aims in our study were to investigate dysfunctional signs of mitochondria in tumor cells and the internal organs in mice under the growth of B16/F10 melanoma.
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Mitochondrial therapy of melanoma B16/F10, pathophysiological parameters of tumor regression
Статья научная
The aim is to evaluate the pathophysiological parameters of the efficacy of liver mitochondrial transplantation in animals with B16/F10 melanoma. Materials and methods. In our experiment we used female and male mice of BALB/c Nude strain (n=28). Experimental groups were as follows: the reference group (n=14) with B16/ F10 melanoma; the main group (n=14) with B16/F10 melanoma + mitochondrial therapy (MC therapy). Statistical analysis of results was carried out with the Statistica 10.0 software. Results. The subcutaneous tumor in the mice of both sexes became detectable on day 5 from the time of the tumor inoculation, and the regressive effect produced by MC therapy was recorded in the males beginning with day 8 of the tumor growth. At the end of the experiment, on day 22, the difference in the average volumes of the tumor node was reported to be 3.2 times, i.e. a significant inhibition of the tumor growth in the group of the males with MC therapy was revealed. In the females on day 5 of the tumor growth, differences in the volume of the tumor focus between the reference group and the group with MC therapy were not recorded, however, a statistically significant difference was found in the sex-related comparison of the groups of the animals with MC therapy. It was determined that in the females with MC therapy, the area of the tumor spot during that period (5 days) was 1.4 times (p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Mitochondrial therapy: a vision of the outlooks for treatment of main twenty-first-century diseases
Статья научная
Mitochondria are dynamic organelles which constantly change their shape, size, and location within the cells. Mitochondrial dynamics is associated with mesenchymal metabolism or epithelial-mesenchymal transition to regulate the stem cell differentiation, proliferation, migration, and apoptosis. The transfer of mitochondria from one cell to another is necessary to improve and maintain homeostasis in an organism. Mitochondrial transplantation is a therapeutic approach that involves an introduction of healthy mitochondria into damaged organs. Recent evidence data have shown that the physiological properties of healthy mitochondria provide their ability to replace damaged mitochondria, with suggesting that replacing damaged mitochondria with healthy mitochondria may protect cells from further damage. Moreover, mitochondria can also be actively released into the extracellular space and potentially be transferred between the cells in the central nervous system. This increased interest in mitochondrial therapy calls for a deeper understanding of the mechanisms, which build the basis for mitochondrial transfer, uptake, and cellular defense. In this review, questions related to the involvement of mitochondria in the pathogenesis of cancer will be discussed. Particular attention will be paid to mitochondrial transplantation as a therapeutic approach to treat the mitochondrial dysfunction under some pathological conditions.
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Статья научная
On models of chronic neurogenic pain (CNP) and the growth of a malignant tumor (metastasizing B16 melanoma) in male mice, we studied an effect produced by mitochondrial therapy (MCT) on the state of the myocardium. Some structural correlates of the compensatory-restorative effect by mitochondria transplanted from healthy recipient rats were revealed. It has been identified that MCT contributes to the preservation of the structural integrity of the myocardial tissue, the inclusion of an auxiliary link in the cellular mechanisms of tissue restoration: fibroblasts, histiocytes, lymphocytes, eosinophils and other connective tissue elements, which implement the intercellular mechanism of information transfer that provides the external regulatory function of MCT. The ability of mitochondria to prevent the DNA decay determines the possibility of initiation of the operation of the nuclear mechanisms of the cardiomyocyte division, which is characteristic of a population of young cells and which indicates the determining position of exogenous mitochondria.
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Modeling of threats in the sphere of medical data storage
Статья научная
In medical institutions of various levels, a large amount of data is stored in electronic form, to ensure the safety of which are presented with special requirements. Ensuring the safety of the storage of medical data should begin with an analysis of existing threats. This article provides a model of threats in the area of data storage, which includes the following components: comunicative, spatial and destructive threat. It is shown that, to date, communicative and spatial threats have minor rates, which can be neglected. The destructive threat is considered in more detail, its components are described. Recommendations for the development of medical data storage systems are given.
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Modern diagnostic methods in oncogastroenterology
Отчет
Diagnostic procedures occupy a special place in the activities of medical specialists, since the accuracy and timeliness of their implementation depends on the determination of the patient’s treatment package, as well as the prognosis of the course of the disease. In the modern period, innovative technologies come to the aid of doctors, one of which is artificial intelligence. Along with other areas of medicine, artificial intelligence (AI) technology is widely used in oncogastroenterology and is used in the process of diagnosis, prediction and image analysis. AI makes it possible to determine with high accuracy the features of the diagnosed pathology and, accordingly, to develop the most effective strategy for the treatment of the patient. The future of oncogastroenterology is based, without a doubt, precisely on the results of high-precision diagnostics, since advanced methods of treating cancer patients can give a significant effect precisely at the early stages of the development of this disease. For this reason, the appeal to AI as an indispensable assistant to diagnosticians in the future should be widely implemented at all levels of polyclinic and inpatient oncological care to the population.
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Modern features of diagnosis and treatment of thoraco-abdominal injuries
Статья научная
The improved algorithm of the diagnosing and treatment tactic of thoracoabdominal injuries can allows for timely diagnosis and the choice of adequate treatment tactics. The important role and opportunities of the endovideosurgical technologies are revealed in the diagnosis and surgical management of patients with thoracic and abdominal trauma. The results of diagnostics and treatment of patients with thoracoabdominal injuries using the diagnostic and treatment tactic algorithm improved by the authors were analyzed. The use of the offered diagnostic and treatment algorithm has improved the results of treatment of this severe category of patients. The clinical effectiveness of minimally invasive methods of the treatment and diagnosing of the thoracoabdominal injury is average 1.1 times higher than traditional surgical approaches
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Modern high-tech approaches to the diagnosis of gastrointestinal diseases
Статья научная
The article discusses modern high-tech approaches to the diagnosis of gastrointestinal diseases. Revealing the relevance of the problem and the importance of accurate and timely diagnosis for the successful treatment of patients, the authors draw attention to the latest methods and technologies used in this field of medicine. The article discusses various diagnostic methods, including endoscopy, ultrasound, computed tomography, magnetic resonance imaging, molecular genetic analyses, as well as the use of artificial intelligence and machine learning to analyze medical data. The advantages and limitations of each method, their effectiveness and development prospects are discussed. The question is also raised about the need for an integrated approach to diagnosis, including a combination of various methods to improve the accuracy and reliability of the results. It is concluded that low-frequency imaging technologies provide a promising strategy for diagnosing diseases of the gastrointestinal tract. These technologies provide more complete information about the disease by integrating multiple contrast agents for imaging.
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