Статьи журнала - Cardiometry
Все статьи: 606
Статья научная
The aim of our research work was to study the level of sex steroids in blood, the tumor and the perifocal zone in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. The experiment was performed in 110 outbred rats of both sexes. Hypothyroidism was induced in animals for 30 days with Mercazolil medication, and then Guerin’s carcinoma was transplanted (the main group). The reference groups included animals with an independent growth of Guerin’s carcinoma and with independent hypothyroidism, as well as intact animals (the norm). On the 18th day of the tumor growth, the animals were sacrificed, and, using standard RIA kits, in the serum, the tumor homogenates and the perifocal zone, the levels of estradiol (E2), testosterone (T) and progesterone (P4) were determined. Results. In comparison with intact animals, hypothyroidism caused an increase in the blood content of E2 in animals of both sexes by 2.2-2.4 times and T by 1.4-16 times, and P4 by 1.7 times only in females, but recorded was a decrease therein in males by 2.4 times. The growth of Guerin’s carcinoma resulted in a 2.5-5.5-fold decrease in E2 in blood of the animals of both sexes, an increase in T by 2.1 times and P4 by 3 times in the females, but a decrease in T by 2.6 times without changing P4 in the males. In the main group, in the animals of both sexes, similarly to the processes in hypothyroidism, the level of E2 and P4 increased by 1.4-1.6 times, and in females also T by 4.4 times, compared with the intact animals. Conclusion. Hypothyroidism and the growth of Guerin’s carcinoma changed E2 in different directions in animals of both sexes the level of sex hormones in blood and shifted the steroid balance in the tumor and its perifocal zone. In the females of the main group, the saturation of the tumor with estrogens, androgens and progesterone decreased, while in the males, on the contrary, the concentration of steroids increased.
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Статья научная
The task of the article is to assess the effect made by an industrial climbing safety system used by an industrial climber, performing his work to provide a harness-based suspended access at low ambient temperatures, on his physiological parameters. The article presents some studies on changes recorded in body surface temperatures, pulse rates, and blood pressure value in an industrial climber depending on the duration of his performance using a harness-based suspended access under ambient air low temperature conditions. The tests have been carried out for various types of thermal protection of the human hip area and the width of the belts of the safety system. The scientific novelty of the study is that it is the first time when such a study has been conducted for a combination of industrial factors, like prolonged suspended condition due to the utilization of the climbing safety system and a low ambient temperature. As a result, it has been found that the physiological parameters are influenced by the width of the safety belts of the safety equipment system and the method of the temperature protection of the hip zone in a climber.
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Статья научная
Aims The response of the cardiovascular system to acupuncture treatment is studied in the present paper. Materials and In the process of study a special device for recording hemodynamic methods parameters as well as the classical acupuncture method was used. The hemodynamic parameters were recorded at the time of needle insertion, during the acupuncture session and after the session. Results The changes in the phase blood volumes were recorded. The influence of the acupuncture on the muscle contraction amplitude during all phases of the cardiac cycle was recorded. Conclusion Appliance of the cardiac cycle phase analysis enables accurate monitoring of the response of the cardiovascular system to acupuncture.
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Статья научная
To study the intensity of lipid peroxidation (LPO) and the activity of the main antioxidant protection enzyme: superoxide dismutase (SOD) in heart tissues and tumors in rats of both genders with Guerin's carcinoma (GC) and the tumor growth against the background of diabetes mellitus (DM). Materials and methods. Our research work was carried out in 80 outbread albino male and female rats, divided into 4 groups, with 10 animals of each gender in a group. The animals of two groups, namely, an intact animal group and a group of rats treated with alloxan DM (with a 5-fold increase in glucose levels) were subcutaneously transplanted with the Guerin's carcinoma (GC) strain cells, and at the same time we used one group of the intact rats and another group of the animals with DM as the references. The content of malondialdehyde (MDA), diene conjugates (DC), and the SOD activity in the heart and the tumor tissues were determined by conventional spectrophotometric methods. Results. The most pronounced changes were found in the heart in the female rats with isolated GC and GC growing against the background of DM: a more than threefold increase in MDA, with a significant increase in DC and a multiple increase in the SOD activity as compared with the intact animals. In the GC tissue, the dependence of the severity of the increase in the MDA content on the size of the tumor was traced: the maximum increase in both parameters was observed in males with GC tumor growing against the background of DM. In the males, the volume of the subcutaneous tumor nodes was 1.8 times greater than that in the reference group and in the females with combined pathology, while in the females with combined pathology the volume of their tumors was 1.3 times less than that in the reference group, although the area of tumor lesions in them was maximum due to extensive metastasizing. Conclusion. DM has changed the specifics of oncogenesis depending on the gender of the animals. The identified gender differences in the redox status of the heart and the tumor in rats with combined pathology contribute to specifics of oncogenesis in males and females and determines their life expectancy.
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Influence of hypothyroidism on the hypothalamic-pituitarygonadal axis in rats with Guerin's tumor
Статья
The thyroid and the gonadal (HPG) regulatory axes are interconnected and act together as a single system and their imbalance leads to pathological responses of the organism [1, 2]. The involvement of thyroid and sex hormones in the development of the malignant process has been discussed for many decades.
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Influence of postoperative magnetotherapy on homeostasis central regulation efficiency
Отчет
Aim The aim of the present research is to study the dynamics of bioelectric markers of the CNS functional state in lung cancer patients during an early postoperative period for the purpose of evaluation of the conducted magnetotherapy adaptive and correcting effects. Materials and methods 25 lung cancer male patients have been examined. The reference group patients received a standard postoperative therapy, while in the main group it has been accompanied by the complex modulated ultra low frequency magnetic field exposure applied to the occipital area. Before the operation and 10 days after it in all the patients EEGs have been recorded unipolarly, according to system “10/20” as well as the galvanic skin resistance measured in reference points using the R. Voll electro-acupuncture method. Results It is demonstrated that the postoperative magnetotherapy application in lung cancer patients is accompanied with a significant exceedance of the spatial synchronization values over the corresponding markers only in case of surgical treatment: in alpha band between the central and temporal area in the left hemisphere, and between the similar areas in the right hemisphere; in beta-band between the symmetrical areas in the temporal and central cortex...
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Статья научная
studying AIF levels in mitochondria in cells of the heart and various organs in female mice with the growth of experimental melanoma B16 / F10 and comorbid pathology
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Статья научная
The aim is to study the content of prekallikrein, kallikreins 1 and 14 (KLK-1 and KLK-14) in mice under the conditions of activation and inhibition of the B16/F10 inoculated melanoma growth. Materials and methods We produced a model of chronic neurogenic pain (CNP, bilateral ligation of sciatic nerves) and a model of the B16/F10 melanoma growth against the background of CNP using female/male mice of the C57BL/6 line (with normal genome, n=75) and the C57BL/6-Plautm1.1bugthisplaughfdhu/GFDhu line (with urokinase knockout (uPA), n=46). The ELISA method was used to determine the content of prekallikrein, KLK1 and KLK14 in the tumor and skin after 3 weeks of carcinogenesis against the background of CNP. Results The initially high content of prekallikrein, KLK-1 and KLK-14 in the skin of intact knockout mice was found. When inhibiting the growth and metastasis of melanoma in the skin of the knockout females, noted was a further increase in the initially high level of prekallikrein and KLK1, and in the tumor in the knockout mice of both genders recorded was a lower content of all the studied enzymes. When activating the growth of melanoma in the state of CNP in the skin of C57BL/6 mice, the level of KLK1 (female) decreased and the concentration of KLK14 (female and male) increased; in the knockout mice the content of prekallikrein and KLK14 decreased, and KLK1 changed multidirectionally. The tumor demonstrated a lower prekallikrein level in all C57BL/6mice and multidirectional changes in KLK1 and KLK14 in females and males. The tumor in the knockout animals showed a lower content of all the studied enzymes, especially pronounced for KLK14. Conclusion The content of prekallikrein, KLK1 and KLK14 varies under activating and inhibiting the growth of melanoma, the changes are of the gender-specific type. It is probable that the functions of the studied enzymes in the skin change not only in case of CNP, but also in case of urokinase deficiency. The tumor itself adapts the performance of the kallikrein-kinin system depending on the metabolic features of the tumor-bearing organism.
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Inhalation health risk assessment of some of heavy metals for kerosene samples in Iraq market
Статья научная
In this study, five heavy metals (Zn, Fe, Pb, Cu, and Cd) concentrations were measured in samples of kerosene (locally only) that collected from different of warehouses oils in Iraq. The measurements have been done using Atomic Absorption Spectrophotometer. Non-cancer risks such as the chronic daily inhalation intake (CDIinh), a Hazard Quotient (HQ), and Haz-ard Index (HI) as well as Cancer Risks (CR) due to inhalation of heavy metals in the kerosene samples were calculated. The results show that, the average values of concentrations in unit ppm (mg/kg) belonging to Zn, Fe, Pb, Cu, and Cd in kerosene samples were 8.14±1.74, 0.127±0.025, 0.017±0.007, 0.15±0.064, and 0.360±0.022, respectively. While, the average value of Haz-ard Index (HI) due to all heave metals in the present work was 0.721± 0.16. Also, the average value of Total Cancer Risk (TCR) due to Cd and Pb were 1.12E-03±4.4E-04. When comparing the results of inhalation health risk, the present work with Worldwide average, we found that the most samples of kerosene samples are safe for using.
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Innovations in laparoscopy: current trends and prospects for the development of surgical techniques
Статья научная
The article examines current trends and prospects for the development of surgical techniques in laparoscopy with an emphasis on innovation. The latest technologies and methods used in laparoscopic surgery, such as robotic surgery, improved video systems, three-dimensional visualization and telemedicine solutions, are highlighted. The authors analyze the benefits of these innovations, including more accurate and effective procedures, shorter patient recovery time, and reduced risk of complications. The challenges facing the introduction of new technologies, including the need for staff training and the high cost of equipment, are also considered. It is concluded that innovations in laparoscopy play a key role in modern surgery and have the potential to significantly improve patient outcomes in the future.
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Статья
At the present stage, the problems of preventive oncology are becoming more and more important, especially, at the stages of blastomogenesis, recurrence and metastasizing of tumors. Preventive measures can also be aimed at regulating the stress syndrome, improving the efficiency and safety of chemoradiotherapy, and improving the quality of life and rehabilitation processes for cancer patients. Promising in this aspect are approaches, which take into account the unique capabilities of natural antitumor geroprotectors: phytoadaptogens (PhA)
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Innovative technologies for the treatment of cervical intraepithelial neoplasia of the cervix
Статья научная
The problem of pathological conditions of the cervix attracts great attention of doctors of many specialties, which is due to the ambiguity of the prognosis of this pathology. The detection of gynecological pathology, including cervical pathology, depends on the use of screening diagnostic methods, improvement of preventive and therapeutic measures carried out in an outpatient setting. In modern medical practice diseases of the cervix uteri occupy a leading position due to the high the frequency of their occurrence, frequent transformation into precancerous conditions, which in turn can be the cause of cervical cancer. Today, both in world practice and in Uzbekistan in the structure of oncological diseases of the genital organs in women cervical cancer is the second most common disease, causing high mortality of patients.
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Inseparable relationship between intellectual services and high-tech medical equipment
Статья обзорная
The social problems in any country, related to public health and demography, induce developments and production of diagnostic and therapeutic medical equipment. Such equipment belongs to high-tech products and requires to be accompanied by intellectual services for a successful promotion of medical products on the market under modern competitive conditions. The authors hereof substantiate the need to develop intellectual services for companies manufacturing high-tech medical equipment. The article treats the concept of intellectual services, the peculiarities of the intellectual services market in Russia, the special features of high-tech medical products promotion, as well as instruments for promoting the intellectual services by high-tech medical equipment manufacturers.
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Instrumental means for identifying personal inclination to protest behavior
Статья научная
The article presents data on the identification by instrumental methods of two groups of respondents with different response options to situations with various kinds of restrictions and pre requisites for interpersonal conflicts, one of which demonstrat ed a tendency to protest behavior as a reaction to restrictions and as a manifestation of a low level of self-control, and the second one showed a tendency to conformism as a manifesta tion of high self-control and internal readiness to follow gener ally accepted behavioral norms.
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Instrumental support for increasing personal resilience against destructive manipulations
Статья научная
The article confirms the possibility of metaphorical description by clients of options for manipulating their behavior that are significant to them. It has been shown that Sandplay Therapy can be used to successfully design and rehearse the desired forms of behavior and form associated sensory standards for subsequent ideomotor training. Evidence is presented of the validity of an assumption that the very elements of such materialized displays of the existing orientation schemes and their photographs support to quickly assess the intensity of the emotional experiences accompanying such modeling and the physiological processes associated with them. It has been established that cardiac measurements followed by calculation of the stress index of the various components of the autonomic nervous system make it possible to assess the level of stress caused by the client’s imagination of a problematic situation for him/her, where he/ she is facing a traumatic manipulation. It is noted that measurements of changes in galvanic skin reactions also allows judging the intensity of experiences that accompany the rebuilding of the associative connection of the depicted items with those manifestations of manipulation of which it is a metaphorical representation. Another assumption has also been confirmed that Sandplay Therapy can be used to effectively prevent some undesired manipulative influences on the client’s personality. At the same time, in addition to establishing the effectiveness of therapeutic procedures, cardiometric measurements and recording of electrodermal activity for the client himself/herself serve as a kind of bio-feedback. Using the latter, the client gets an opportunity to assess how much the response to metaphorical representations of manipulative influences corresponds to how exactly he/she would like to act if they are detected.
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Статья научная
Diabetes mellitus is an additional risk factor for the development of heart diseases, cardiovascular dysfunction and malignant tumors. The aim of the study was to analyze levels of IGF and IGFBP in heart samples of animals with diabetes mellitus and/ or growing Guerin’s carcinoma. The study included white outbred rats of both genders weighing 180-220 g. The rats of each gender were divided into groups of 8 animals: the intact group; test groups 1 (with diabetes) and 2 (with transplanted Guerin’s carcinoma); the main group (transplanted Guerin’s carcinoma growing in the presence of diabetes mellitus). Levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-2 were measured by ELISA (Mediagnost, Germany) in heart homogenates in animals of all groups
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Статья научная
At the present stage, the introduction of technological inno-vations into medical practice is extremely important because it allows to increase the effectiveness of both diagnostic pro-cedures and the process of providing medical care to patients. At the same time, certain innovative technologies can radically change the landscape of medical procedures. Of particular in-terest in this context is the specialty of a trauma surgeon, where the innovations under consideration make it possible to im-prove patient treatment results, reduce complications, reduce recovery time and increase the experience of surgeons. Robotic surgery has become a significant breakthrough in modern medicine in general and in the practice of a trauma surgeon in particular. This technology allows surgeons to per-form complex operations with high precision and minimal im-pact on surrounding tissues, which contributes to faster recov-ery of patients and reduces the risk of complications. Robotic systems ensure the precise execution of surgical movements, robots allow surgeons to perform movements in a wider range than is possible using human hands. In addition, through the use of these systems, the surgeon, through the use of three-di-mensional cameras, receives a good visualization of the surgical field. Accordingly, the purpose of this work is to study the fea-tures of integrating modern technologies into the practice of a trauma surgeon.
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Intelligent digitalization of cardiovascular risks
Статья научная
The aim of the study was to develop a mathematical model of the risks of the cardiovascular system based on the selected factors affecting cardiovascular diseases (CVD) and to test the developed mathematical model on a sample of clinical examples. CVD risk factors was grouped by types: biological indicators (anthropometric, biochemical, morphological, physiological), disease indicators, social indicators. An assessment of the degree of risk for each of the indicators was carried out by calculating the degree of risk using the membership formula, then evaluating the hazard class (according to the degree of risk) using a logical-linguistic model and a training algorithm for the neural fuzzy classifier of the network. The correctness of the risk determination by the developed model was confirmed by the analyzed 60 verified cases of acute cerebrovascular accident (18 men and 42 women). The analysis of the test results of the constructed neuro-fuzzy classifier allows us to conclude that it works satisfactorily even when using incomplete information, which makes it possible to use it for prompt decision-making. The results of testing on clinical examples, with an acceptable level of significance of a type I error of 0.05, showed that the risk was determined correctly. The factors influencing the risk of CVD are identified and designated as the corresponding linguistic variables. A logical-linguistic model was built, from which a transition was made to a hybrid neuro-fuzzy classifier, which allows assessing the influence of the identified factors on the level of risk of CVD. As a result of approbation of the model of intellectual digitalization of risks of the cardiovascular system on real clinical examples, it was confirmed that the risk was determined correctly, which means that it is possible to assert about the prospects for introducing this model into clinical practice and guaranteeing medical specialist more accurate diagnosis and optimization of their activities.
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Interaction between the mother and the fetus in the aspect of immunology
Статья научная
The article deals with the interaction between the mother and the fetus in the aspect of immunology. The immunological problems which the maternal immune system may encounter in pregnancy and their potential negative effects on the fetal health are also of interest to us. Therefore, it is necessary to consider the features of the interaction between the fetus and the mother, which will allow assessing the prospects for future research in the field of the interaction between the maternal and fetal immune systems for more effective prevention and treatment of immunological problems in pregnancy.
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Interdisciplinary educational approaches in healthcare organizations
Статья научная
Background: Healthcare professionals’ perception of Interdisciplinary Education is an essential factor that affects their acceptance of this approach to education. From the literature related to patient safety, it has been identified widely that healthcare team communication and performance are critical to providing safe care to the patient. Poor organization and team dynamics among healthcare professionals appear to impact the safety and quality of patient care. The lack of Interdisciplinary Education in healthcare institutions in the Kingdom of Saudi Arabia negatively impacts the work dynamics of the healthcare team. Results: The study results showed that the majority of health care workers showed a high awareness level for IPE. Therefore, female nurses who have been working in special units and have experience of more than five years are perceived more than other specialties. Also, health workers in special units showed a higher percentage than in the general wards, and females were ready more than males. Only one item helped to determine the differences in perception which is the “perceived need for cooperation”. Conclusions: IPC should be initiated by universities than by health organizations starting at the level of leaders of medicine, nursing, and other disciplines who should be aware of the importance of IPC that would benefit patients as well as health institutions. Leaders must take IPC cooperation seriously by putting it into consideration in the vision of departments and thus starting to establish small-cooperated teams, which include various specialties.
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